| http://purl.uniprot.org/citations/22438254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22438254 | http://www.w3.org/2000/01/rdf-schema#comment | "In response to antigens and cytokines, mouse B cells undergo class-switch recombination (CSR) and differentiate into Ig-secreting cells. T-bet, a T-box transcription factor that is up-regulated in lymphocytes by IFN-γ or IL-27, was shown to regulate CSR to IgG2a after T cell-independent B-cell stimulations. However, the molecular mechanisms controlling this process remain unclear. In the present study, we show that inactivation of the Ets-1 transcription factor results in a severe decrease in IgG2a secretion in vivo and in vitro. No T-bet expression was observed in Ets-1-deficient (Ets-1(-/-)) B cells stimulated with IFN-γ and lipopolysaccharide, and forced expression of T-bet in these cells rescued IgG2a secretion. Furthermore, we identified a transcriptional enhancer in the T-bet locus with an activity in B cells that relies on ETS-binding sites. After IFN-γ stimulation of Ets-1(-/-) B cells, activated Stat1, which forms a complex with Ets-1 in wild-type cells, no longer binds to the T-bet enhancer or promotes histone modifications at this site. These results demonstrate that Ets-1 is critical for IgG2a CSR and acts as an essential cofactor for Stat1 in the regulation of T-bet expression in B cells."xsd:string |
| http://purl.uniprot.org/citations/22438254 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2011-09-378182"xsd:string |
| http://purl.uniprot.org/citations/22438254 | http://purl.uniprot.org/core/author | "Fermand J.P."xsd:string |
| http://purl.uniprot.org/citations/22438254 | http://purl.uniprot.org/core/author | "Nguyen H.V."xsd:string |
| http://purl.uniprot.org/citations/22438254 | http://purl.uniprot.org/core/author | "Bories J.C."xsd:string |
| http://purl.uniprot.org/citations/22438254 | http://purl.uniprot.org/core/author | "Chemin K."xsd:string |
| http://purl.uniprot.org/citations/22438254 | http://purl.uniprot.org/core/author | "Arnulf B."xsd:string |
| http://purl.uniprot.org/citations/22438254 | http://purl.uniprot.org/core/author | "Mouly E."xsd:string |
| http://purl.uniprot.org/citations/22438254 | http://purl.uniprot.org/core/author | "Despres R."xsd:string |
| http://purl.uniprot.org/citations/22438254 | http://purl.uniprot.org/core/author | "Luinaud R."xsd:string |
| http://purl.uniprot.org/citations/22438254 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22438254 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/22438254 | http://purl.uniprot.org/core/pages | "4174-4181"xsd:string |
| http://purl.uniprot.org/citations/22438254 | http://purl.uniprot.org/core/title | "The Ets-1 transcription factor is required for Stat1-mediated T-bet expression and IgG2a class switching in mouse B cells."xsd:string |
| http://purl.uniprot.org/citations/22438254 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/22438254 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22438254 |
| http://purl.uniprot.org/citations/22438254 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22438254 |
| http://purl.uniprot.org/uniprot/#_A0A087WSP5-mappedCitation-22438254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22438254 |
| http://purl.uniprot.org/uniprot/#_A0A087WRI1-mappedCitation-22438254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22438254 |
| http://purl.uniprot.org/uniprot/#_A0A087WSQ5-mappedCitation-22438254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22438254 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MPR7-mappedCitation-22438254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22438254 |
| http://purl.uniprot.org/uniprot/#_P42225-mappedCitation-22438254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22438254 |
| http://purl.uniprot.org/uniprot/#_E9PWI8-mappedCitation-22438254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22438254 |
| http://purl.uniprot.org/uniprot/#_Q540Q5-mappedCitation-22438254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22438254 |