| http://purl.uniprot.org/citations/22441692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22441692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22441692 | http://www.w3.org/2000/01/rdf-schema#comment | "The posttranslational regulation of mammalian clock proteins has been assigned a time-keeping function, but seems to have more essential roles. Here we show that c-Jun N-terminal kinase (JNK), identified by inhibitor screening of BMAL1 phosphorylation at Ser 520/Thr 527/Ser 592, confers dynamic regulation on the clock. Knockdown of JNK1 and JNK2 abrogates BMAL1 phosphorylation and lengthens circadian period in fibroblasts. Mice deficient for neuron-specific isoform JNK3 have altered behavioural rhythms, with longer free-running period and compromised phase shifts to light. The locomotor rhythms are insensitive to intensity variance of constant light, deviating from Aschoff's rule. Thus, JNK regulates a core characteristic of the circadian clock by controlling the oscillation speed and the phase in response to light."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2012.37"xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2012.37"xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Doi H."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Doi H."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Imamura K."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Imamura K."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Wada N."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Wada N."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Nakajima H."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Nakajima H."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Hamada T."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Hamada T."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Honma S."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Honma S."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Honma K."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Honma K."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Fukada Y."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Fukada Y."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Yoshitane H."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Yoshitane H."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Ono D."xsd:string |
| http://purl.uniprot.org/citations/22441692 | http://purl.uniprot.org/core/author | "Ono D."xsd:string |