| http://purl.uniprot.org/citations/22445341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22445341 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendrite arborization and synapse formation are essential for wiring the neural circuitry. The evolutionarily conserved NDR1/2 kinase pathway, important for polarized growth from yeast to mammals, controls dendrite growth and morphology in the worm and fly. The function of NDR1/2 in mammalian neurons and their downstream effectors were not known. Here we show that the expression of dominant negative (kinase-dead) NDR1/2 mutants or siRNA increase dendrite length and proximal branching of mammalian pyramidal neurons in cultures and in vivo, whereas the expression of constitutively active NDR1/2 has the opposite effect. Moreover, NDR1/2 contributes to dendritic spine development and excitatory synaptic function. We further employed chemical genetics and identified NDR1/2 substrates in the brain, including two proteins involved in intracellular vesicle trafficking: AAK1 (AP-2 associated kinase) and Rabin8, a GDP/GTP exchange factor (GEF) of Rab8 GTPase. We finally show that AAK1 contributes to dendrite growth regulation, and Rabin8 regulates spine development."xsd:string |
| http://purl.uniprot.org/citations/22445341 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2012.01.019"xsd:string |
| http://purl.uniprot.org/citations/22445341 | http://purl.uniprot.org/core/author | "Burlingame A.L."xsd:string |
| http://purl.uniprot.org/citations/22445341 | http://purl.uniprot.org/core/author | "Li G."xsd:string |
| http://purl.uniprot.org/citations/22445341 | http://purl.uniprot.org/core/author | "Shokat K.M."xsd:string |
| http://purl.uniprot.org/citations/22445341 | http://purl.uniprot.org/core/author | "Jan L.Y."xsd:string |
| http://purl.uniprot.org/citations/22445341 | http://purl.uniprot.org/core/author | "Jan Y.N."xsd:string |
| http://purl.uniprot.org/citations/22445341 | http://purl.uniprot.org/core/author | "Pleasure S.J."xsd:string |
| http://purl.uniprot.org/citations/22445341 | http://purl.uniprot.org/core/author | "Hertz N.T."xsd:string |
| http://purl.uniprot.org/citations/22445341 | http://purl.uniprot.org/core/author | "Ultanir S.K."xsd:string |
| http://purl.uniprot.org/citations/22445341 | http://purl.uniprot.org/core/author | "Ge W.P."xsd:string |
| http://purl.uniprot.org/citations/22445341 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22445341 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/22445341 | http://purl.uniprot.org/core/pages | "1127-1142"xsd:string |
| http://purl.uniprot.org/citations/22445341 | http://purl.uniprot.org/core/title | "Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development."xsd:string |
| http://purl.uniprot.org/citations/22445341 | http://purl.uniprot.org/core/volume | "73"xsd:string |
| http://purl.uniprot.org/citations/22445341 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22445341 |
| http://purl.uniprot.org/citations/22445341 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22445341 |
| http://purl.uniprot.org/uniprot/Q62739#attribution-09A4C5E8AC66FA688040B401598BBCD3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22445341 |
| http://purl.uniprot.org/uniprot/Q62739#attribution-9742F864F53A7338B5B9F1700ADAF98F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22445341 |
| http://purl.uniprot.org/uniprot/G3V9Q4#attribution-35B28C3D1D91F871E3A206C5EEC9FE43 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22445341 |
| http://purl.uniprot.org/uniprot/A0A0U1RS40#attribution-35B28C3D1D91F871E3A206C5EEC9FE43 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22445341 |
| http://purl.uniprot.org/uniprot/A6JJT1#attribution-35B28C3D1D91F871E3A206C5EEC9FE43 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22445341 |
| http://purl.uniprot.org/uniprot/A0A8I5ZVV6#attribution-35B28C3D1D91F871E3A206C5EEC9FE43 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22445341 |