http://purl.uniprot.org/citations/22449966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/22449966 | http://www.w3.org/2000/01/rdf-schema#comment | "Rho-family small GTPases regulate epithelial cell sheet migration by organizing actin and myosin during wound healing. Here, we report that Pak3, but not Pak1, is a downstream target protein for Rac1 in wound closure of the Drosophila larval epidermis. Pak3-deficient larvae failed to close a wound hole and this defect was not rescued by Pak1 expression, indicating differential functions of the two proteins. Pak3 localized to the wound margin, which selectively required Rac1. Pak3-deficient larvae showed severe defects in actin-myosin organization at the wound margin and in submarginal cells, which was reminiscent of the phenotypes of Rac1-deficient larvae. These results suggest that Pak3 specifically mediates Rac1 signaling in organizing actin and myosin during Drosophila epidermal wound healing."xsd:string |
http://purl.uniprot.org/citations/22449966 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.01.061"xsd:string |
http://purl.uniprot.org/citations/22449966 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
http://purl.uniprot.org/citations/22449966 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
http://purl.uniprot.org/citations/22449966 | http://purl.uniprot.org/core/author | "Kim M.J."xsd:string |
http://purl.uniprot.org/citations/22449966 | http://purl.uniprot.org/core/author | "Kwon Y.C."xsd:string |
http://purl.uniprot.org/citations/22449966 | http://purl.uniprot.org/core/author | "Baek S.H."xsd:string |
http://purl.uniprot.org/citations/22449966 | http://purl.uniprot.org/core/author | "Choe K.M."xsd:string |
http://purl.uniprot.org/citations/22449966 | http://purl.uniprot.org/core/author | "Cho H.W."xsd:string |
http://purl.uniprot.org/citations/22449966 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
http://purl.uniprot.org/citations/22449966 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
http://purl.uniprot.org/citations/22449966 | http://purl.uniprot.org/core/pages | "772-777"xsd:string |
http://purl.uniprot.org/citations/22449966 | http://purl.uniprot.org/core/title | "Requirement for Pak3 in Rac1-induced organization of actin and myosin during Drosophila larval wound healing."xsd:string |
http://purl.uniprot.org/citations/22449966 | http://purl.uniprot.org/core/volume | "586"xsd:string |
http://purl.uniprot.org/citations/22449966 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22449966 |
http://purl.uniprot.org/citations/22449966 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22449966 |
http://purl.uniprot.org/uniprot/#_E1JHD6-mappedCitation-22449966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22449966 |
http://purl.uniprot.org/uniprot/#_A0A0B4KGS4-mappedCitation-22449966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22449966 |
http://purl.uniprot.org/uniprot/#_B7Z0W0-mappedCitation-22449966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22449966 |
http://purl.uniprot.org/uniprot/#_M9NFF8-mappedCitation-22449966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22449966 |
http://purl.uniprot.org/uniprot/#_M9PBH7-mappedCitation-22449966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22449966 |
http://purl.uniprot.org/uniprot/#_M9PBU2-mappedCitation-22449966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22449966 |
http://purl.uniprot.org/uniprot/#_P40792-mappedCitation-22449966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22449966 |
http://purl.uniprot.org/uniprot/#_P40793-mappedCitation-22449966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22449966 |