| http://purl.uniprot.org/citations/22451650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22451650 | http://www.w3.org/2000/01/rdf-schema#comment | "DREAM is a Ca(2+)-dependent transcriptional repressor highly expressed in neuronal cells. A number of genes have already been identified as the target of its regulation. Targeted analysis performed on cerebella from transgenic mice expressing a dominant active DREAM mutant (daDREAM) showed a drastic reduction of the amount of transcript of Ca(2+)-activated nucleotidase 1 (CANT1), an endoplasmic reticulum (ER)-Golgi resident Ca(2+)-dependent nucleoside diphosphatase that has been suggested to have a role in glucosylation reactions related to the quality control of proteins in the ER and the Golgi apparatus. CANT1 down-regulation was also found in neuroblastoma SH-SY5Y cells stably overexpressing wild type (wt) DREAM or daDREAM, thus providing a simple cell model to investigate the protein maturation pathway. Pulse-chase experiments demonstrated that the down-regulation of CANT1 is associated with reduced protein secretion and increased degradation rates. Importantly, overexpression of wtDREAM or daDREAM augmented the expression of the EDEM1 gene, which encodes a key component of the ER-associated degradation pathway, suggesting an alternative pathway to enhanced protein degradation. Restoring CANT1 levels in neuroblastoma clones recovered the phenotype, thus confirming a key role of CANT1, and of the regulation of its gene by DREAM, in the control of protein synthesis and degradation."xsd:string |
| http://purl.uniprot.org/citations/22451650 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.304733"xsd:string |
| http://purl.uniprot.org/citations/22451650 | http://purl.uniprot.org/core/author | "Brini M."xsd:string |
| http://purl.uniprot.org/citations/22451650 | http://purl.uniprot.org/core/author | "Carafoli E."xsd:string |
| http://purl.uniprot.org/citations/22451650 | http://purl.uniprot.org/core/author | "Cali T."xsd:string |
| http://purl.uniprot.org/citations/22451650 | http://purl.uniprot.org/core/author | "Fedrizzi L."xsd:string |
| http://purl.uniprot.org/citations/22451650 | http://purl.uniprot.org/core/author | "Ottolini D."xsd:string |
| http://purl.uniprot.org/citations/22451650 | http://purl.uniprot.org/core/author | "Mellstrom B."xsd:string |
| http://purl.uniprot.org/citations/22451650 | http://purl.uniprot.org/core/author | "Naranjo J.R."xsd:string |
| http://purl.uniprot.org/citations/22451650 | http://purl.uniprot.org/core/author | "Gomez-Villafuertes R."xsd:string |
| http://purl.uniprot.org/citations/22451650 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22451650 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22451650 | http://purl.uniprot.org/core/pages | "18478-18491"xsd:string |
| http://purl.uniprot.org/citations/22451650 | http://purl.uniprot.org/core/title | "Ca2+-activated nucleotidase 1, a novel target gene for the transcriptional repressor DREAM (downstream regulatory element antagonist modulator), is involved in protein folding and degradation."xsd:string |
| http://purl.uniprot.org/citations/22451650 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/22451650 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22451650 |
| http://purl.uniprot.org/citations/22451650 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22451650 |
| http://purl.uniprot.org/uniprot/#_P0C092-mappedCitation-22451650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22451650 |
| http://purl.uniprot.org/uniprot/#_A2AHT3-mappedCitation-22451650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22451650 |
| http://purl.uniprot.org/uniprot/#_Q3TMU2-mappedCitation-22451650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22451650 |
| http://purl.uniprot.org/uniprot/#_Q3YAA9-mappedCitation-22451650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22451650 |
| http://purl.uniprot.org/uniprot/#_Q3YAB0-mappedCitation-22451650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22451650 |
| http://purl.uniprot.org/uniprot/#_Q99PI1-mappedCitation-22451650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22451650 |
| http://purl.uniprot.org/uniprot/#_Q9QXT8-mappedCitation-22451650 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22451650 |