| http://purl.uniprot.org/citations/22451666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22451666 | http://www.w3.org/2000/01/rdf-schema#comment | "B cell receptor (BCR)-mediated antigen (Ag) processing and presentation lead to B cell-T cell interactions, which support affinity maturation and immunoglobulin class switching. These interactions are supported by generation of peptide-MHC class II complexes in multivesicular body-like MIIC compartments of B cells. Previous studies have shown that trafficking of Ag·BCR complexes to MVB-like MIIC occurs via an ubiquitin-dependent pathway and that ubiquitination of Ag·BCR complexes occurs by an Src family kinase signaling-dependent mechanism that is restricted to lipid raft-resident Ag·BCR complexes. This study establishes that downstream Syk-dependent BCR signaling is also required for BCR ubiquitination and BCR-mediated antigen processing and presentation. Knockdown studies reveal that of the two known Syk-binding E3 ubiquitin ligases c-Cbl and Cbl-b, only c-Cbl appears to have a central role in BCR ubiquitination, trafficking to MIIC, and ubiquitin-dependent BCR-mediated antigen processing and presentation. These results establish the novel role for Syk signaling and the Syk-binding ubiquitin ligase c-Cbl in the BCR-mediated processing and presentation of cognate antigen and define one mechanism by which antigen-induced BCR ubiquitination is modulated to impact the initiation and maturation of the humoral immune response."xsd:string |
| http://purl.uniprot.org/citations/22451666 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.357640"xsd:string |
| http://purl.uniprot.org/citations/22451666 | http://purl.uniprot.org/core/author | "Rosa S."xsd:string |
| http://purl.uniprot.org/citations/22451666 | http://purl.uniprot.org/core/author | "Drake J.R."xsd:string |
| http://purl.uniprot.org/citations/22451666 | http://purl.uniprot.org/core/author | "Katkere B."xsd:string |
| http://purl.uniprot.org/citations/22451666 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22451666 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22451666 | http://purl.uniprot.org/core/pages | "16636-16644"xsd:string |
| http://purl.uniprot.org/citations/22451666 | http://purl.uniprot.org/core/title | "The Syk-binding ubiquitin ligase c-Cbl mediates signaling-dependent B cell receptor ubiquitination and B cell receptor-mediated antigen processing and presentation."xsd:string |
| http://purl.uniprot.org/citations/22451666 | http://purl.uniprot.org/core/volume | "287"xsd:string |
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