| http://purl.uniprot.org/citations/22451924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22451924 | http://www.w3.org/2000/01/rdf-schema#comment | "To address the role of Tpl2, a MAP3K8 that regulates innate/adaptive immunity and inflammation, in intestinal tumorigenesis, we crossed a Tpl2 KO allele into the Apc(min/+) genetic background. Here, we show that Apc(min/+)/Tpl2(-/-) mice exhibit a fivefold increase in the number of intestinal adenomas. Bone marrow transplantation experiments revealed that the enhancement of polyposis was partially hematopoietic cell-driven. Consistent with this observation, Tpl2 ablation promoted intestinal inflammation. IL-10 levels and regulatory T-cell numbers were lower in the intestines of Tpl2(-/-) mice, independent of Apc and polyp status, suggesting that they were responsible for the initiation of the enhancement of tumorigenesis caused by the ablation of Tpl2. The low IL-10 levels correlated with defects in mTOR activation and Stat3 phosphorylation in Toll-like receptor-stimulated macrophages and with a defect in inducible regulatory T-cell generation and function. Both polyp numbers and inflammation increased progressively with time. The rate of increase of both, however, was more rapid in Apc(min/+)/Tpl2(-/-) mice, suggesting that the positive feedback initiated by inflammatory signals originating in developing polyps is more robust in these mice. This may be because these mice have a higher intestinal polyp burden as a result of the enhancement of tumor initiation."xsd:string |
| http://purl.uniprot.org/citations/22451924 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1115098109"xsd:string |
| http://purl.uniprot.org/citations/22451924 | http://purl.uniprot.org/core/author | "Mao C."xsd:string |
| http://purl.uniprot.org/citations/22451924 | http://purl.uniprot.org/core/author | "Ren W."xsd:string |
| http://purl.uniprot.org/citations/22451924 | http://purl.uniprot.org/core/author | "Tsichlis P.N."xsd:string |
| http://purl.uniprot.org/citations/22451924 | http://purl.uniprot.org/core/author | "Siracusa L.D."xsd:string |
| http://purl.uniprot.org/citations/22451924 | http://purl.uniprot.org/core/author | "Eliopoulos A.G."xsd:string |
| http://purl.uniprot.org/citations/22451924 | http://purl.uniprot.org/core/author | "Tsatsanis C."xsd:string |
| http://purl.uniprot.org/citations/22451924 | http://purl.uniprot.org/core/author | "Khazaie K."xsd:string |
| http://purl.uniprot.org/citations/22451924 | http://purl.uniprot.org/core/author | "Gounaris E."xsd:string |
| http://purl.uniprot.org/citations/22451924 | http://purl.uniprot.org/core/author | "Serebrennikova O.B."xsd:string |
| http://purl.uniprot.org/citations/22451924 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22451924 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/22451924 | http://purl.uniprot.org/core/pages | "E1082-91"xsd:string |
| http://purl.uniprot.org/citations/22451924 | http://purl.uniprot.org/core/title | "Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation."xsd:string |
| http://purl.uniprot.org/citations/22451924 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/22451924 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22451924 |
| http://purl.uniprot.org/citations/22451924 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22451924 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUQ3-mappedCitation-22451924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22451924 |
| http://purl.uniprot.org/uniprot/#_B2RUG9-mappedCitation-22451924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22451924 |
| http://purl.uniprot.org/uniprot/#_E9QLQ9-mappedCitation-22451924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22451924 |
| http://purl.uniprot.org/uniprot/#_F6Z405-mappedCitation-22451924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22451924 |
| http://purl.uniprot.org/uniprot/#_P70382-mappedCitation-22451924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22451924 |
| http://purl.uniprot.org/uniprot/#_E9Q4H1-mappedCitation-22451924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22451924 |