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http://purl.uniprot.org/citations/22458338http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22458338http://www.w3.org/2000/01/rdf-schema#comment"

Background

Human T-cell leukemia virus type 1 (HTLV-1) and type 2 both target T lymphocytes, yet induce radically different phenotypic outcomes. HTLV-1 is a causative agent of Adult T-cell leukemia (ATL), whereas HTLV-2, highly similar to HTLV-1, causes no known overt disease. HTLV gene products are engaged in a dynamic struggle of activating and antagonistic interactions with host cells. Investigations focused on one or a few genes have identified several human factors interacting with HTLV viral proteins. Most of the available interaction data concern the highly investigated HTLV-1 Tax protein. Identifying shared and distinct host-pathogen protein interaction profiles for these two viruses would enlighten how they exploit distinctive or common strategies to subvert cellular pathways toward disease progression.

Results

We employ a scalable methodology for the systematic mapping and comparison of pathogen-host protein interactions that includes stringent yeast two-hybrid screening and systematic retest, as well as two independent validations through an additional protein interaction detection method and a functional transactivation assay. The final data set contained 166 interactions between 10 viral proteins and 122 human proteins. Among the 166 interactions identified, 87 and 79 involved HTLV-1 and HTLV-2 -encoded proteins, respectively. Targets for HTLV-1 and HTLV-2 proteins implicate a diverse set of cellular processes including the ubiquitin-proteasome system, the apoptosis, different cancer pathways and the Notch signaling pathway.

Conclusions

This study constitutes a first pass, with homogeneous data, at comparative analysis of host targets for HTLV-1 and -2 retroviruses, complements currently existing data for formulation of systems biology models of retroviral induced diseases and presents new insights on biological pathways involved in retroviral infection."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.org/dc/terms/identifier"doi:10.1186/1742-4690-9-26"xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Martin M."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Vidal M."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Vertommen D."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Hill D.E."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Burny A."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Kettmann R."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Hao T."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Cusick M.E."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Hirozane-Kishikawa T."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Navratil V."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Van Lint C."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Lemmens I."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Tavernier J."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Dricot A."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Simonis N."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Rual J.F."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Twizere J.C."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Klitgord N."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Dequiedt F."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Daakour S."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Gatot J.S."xsd:string
http://purl.uniprot.org/citations/22458338http://purl.uniprot.org/core/author"Boxus M."xsd:string
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