| http://purl.uniprot.org/citations/22460555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22460555 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveObesity promotes hypertension, but it is unclear if sex differences exist in obesity-related hypertension. Angiotensin converting enzyme 2 (ACE2) converts angiotensin II (AngII) to angiotensin-(1-7) (Ang-[1-7]), controlling peptide balance. We hypothesized that tissue-specific regulation of ACE2 by high-fat (HF) feeding and sex hormones contributes to sex differences in obesity-hypertension.Methods and resultsHF-fed females gained more body weight and fat mass than males. HF-fed males exhibiting reduced kidney ACE2 activity had increased plasma angiotensin II levels and decreased plasma Ang-(1-7) levels. In contrast, HF-fed females exhibiting elevated adipose ACE2 activity had increased plasma Ang-(1-7) levels. HF-fed males had elevated systolic and diastolic blood pressure that were abolished by losartan. In contrast, HF-fed females did not exhibit increased systolic blood pressure until females were administered the Ang-(1-7) receptor antagonist, D-Ala-Ang-(1-7). Deficiency of ACE2 increased systolic blood pressure in HF-fed males and females, which was abolished by losartan. Ovariectomy of HF-fed female mice reduced adipose ACE2 activity and plasma Ang-(1-7) levels, and promoted obesity-hypertension. Finally, estrogen, but not other sex hormones, increased adipocyte ACE2 mRNA abundance.ConclusionsThese results demonstrate that tissue-specific regulation of ACE2 by diet and sex hormones contributes to sex differences in obesity-hypertension."xsd:string |
| http://purl.uniprot.org/citations/22460555 | http://purl.org/dc/terms/identifier | "doi:10.1161/atvbaha.112.248559"xsd:string |
| http://purl.uniprot.org/citations/22460555 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/22460555 | http://purl.uniprot.org/core/author | "Shoemaker R."xsd:string |
| http://purl.uniprot.org/citations/22460555 | http://purl.uniprot.org/core/author | "Cassis L.A."xsd:string |
| http://purl.uniprot.org/citations/22460555 | http://purl.uniprot.org/core/author | "Gupte M."xsd:string |
| http://purl.uniprot.org/citations/22460555 | http://purl.uniprot.org/core/author | "Boustany-Kari C.M."xsd:string |
| http://purl.uniprot.org/citations/22460555 | http://purl.uniprot.org/core/author | "Thatcher S.E."xsd:string |
| http://purl.uniprot.org/citations/22460555 | http://purl.uniprot.org/core/author | "Karounos M."xsd:string |
| http://purl.uniprot.org/citations/22460555 | http://purl.uniprot.org/core/author | "Yiannikouris F."xsd:string |
| http://purl.uniprot.org/citations/22460555 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22460555 | http://purl.uniprot.org/core/name | "Arterioscler Thromb Vasc Biol"xsd:string |
| http://purl.uniprot.org/citations/22460555 | http://purl.uniprot.org/core/pages | "1392-1399"xsd:string |
| http://purl.uniprot.org/citations/22460555 | http://purl.uniprot.org/core/title | "Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice."xsd:string |
| http://purl.uniprot.org/citations/22460555 | http://purl.uniprot.org/core/volume | "32"xsd:string |
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