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Background

Maternal diabetes causes neural tube defects (NTDs) in the embryos via activating protein kinase Cs (PKCs), which regulate programmed cell death (apoptosis). The aims of this study are to investigate the role of proapoptotic PKCδ in NTD formation and the underlying mechanisms.

Methods

PKCδ heterozygous (pkcδ(+/-)) female mice were diabetic (DM) induced by intravenous injection of streptozotocin. Occurrence of NTDs was evaluated at embryonic day 11.5 and compared between wild type (WT) and PKCδ homozygous (pkcδ(-/-)) embryos. Changes in oxidative and endoplasmic reticulum (ER) stress-associated factors and stress-response c-Jun N-terminal kinases (JNKs) were assessed using Western blot assay.

Results

Compared to DM/WT, the DM/PKCδ(-/-) embryos had significantly lower NTD rate and lower levels of oxidative and ER stress factors and JNK activation. These values were similar to those in the non-diabetic control group.

Conclusion

PKCδ plays a critical role in diabetes-induced NTDs, potentially through increasing oxidative and ER stress and JNK-associated stress-response pathways."xsd:string
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http://purl.uniprot.org/citations/22463764http://purl.uniprot.org/core/author"Cao Y."xsd:string
http://purl.uniprot.org/citations/22463764http://purl.uniprot.org/core/author"Zhao Z."xsd:string
http://purl.uniprot.org/citations/22463764http://purl.uniprot.org/core/author"Eckert R.L."xsd:string
http://purl.uniprot.org/citations/22463764http://purl.uniprot.org/core/author"Reece E.A."xsd:string
http://purl.uniprot.org/citations/22463764http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22463764http://purl.uniprot.org/core/name"J Matern Fetal Neonatal Med"xsd:string
http://purl.uniprot.org/citations/22463764http://purl.uniprot.org/core/pages"2020-2024"xsd:string
http://purl.uniprot.org/citations/22463764http://purl.uniprot.org/core/title"The essential role of protein kinase Cdelta in diabetes-induced neural tube defects."xsd:string
http://purl.uniprot.org/citations/22463764http://purl.uniprot.org/core/volume"25"xsd:string
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