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| http://purl.uniprot.org/citations/22466669 | http://www.w3.org/2000/01/rdf-schema#comment | "Germinal centers require CD4⁺ follicular helper T cells (TFH cells), whose hallmark is expression of the transcriptional repressor Bcl-6, the chemokine receptor CXCR5 and interleukin 21 (IL-21). To track the development and fate of TFH cells, we generated an IL-21 reporter mouse by introducing sequence encoding green fluorescent protein (GFP) into the Il21 locus; these mice had expression of IL-21–GFP in CD4⁺CXCR5⁺PD-1⁺ TFH cells. IL-21–GFP⁺ TFH cells were multifunctional helper cells that coexpressed several cytokines, including interferon-g (IFN-g), IL-2 and IL-4. TFH cells proliferated and gave rise to transferrable memory cells with plasticity, which differentiated after recall into conventional effector helper T cells and TFH cells. Thus, we demonstrated that TFH cells were not terminally differentiated but instead retained the flexibility to be recruited into other helper T cell subsets and nonlymphoid tissues."xsd:string |
| http://purl.uniprot.org/citations/22466669 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2261"xsd:string |
| http://purl.uniprot.org/citations/22466669 | http://purl.uniprot.org/core/author | "Light A."xsd:string |
| http://purl.uniprot.org/citations/22466669 | http://purl.uniprot.org/core/author | "Nutt S.L."xsd:string |
| http://purl.uniprot.org/citations/22466669 | http://purl.uniprot.org/core/author | "Kallies A."xsd:string |
| http://purl.uniprot.org/citations/22466669 | http://purl.uniprot.org/core/author | "Belz G.T."xsd:string |
| http://purl.uniprot.org/citations/22466669 | http://purl.uniprot.org/core/author | "Tarlinton D.M."xsd:string |
| http://purl.uniprot.org/citations/22466669 | http://purl.uniprot.org/core/author | "Luthje K."xsd:string |
| http://purl.uniprot.org/citations/22466669 | http://purl.uniprot.org/core/author | "Shimohakamada Y."xsd:string |
| http://purl.uniprot.org/citations/22466669 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22466669 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/22466669 | http://purl.uniprot.org/core/pages | "491-498"xsd:string |
| http://purl.uniprot.org/citations/22466669 | http://purl.uniprot.org/core/title | "The development and fate of follicular helper T cells defined by an IL-21 reporter mouse."xsd:string |
| http://purl.uniprot.org/citations/22466669 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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