| http://purl.uniprot.org/citations/2247050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2247050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2247050 | http://www.w3.org/2000/01/rdf-schema#comment | "Two signals are required for meiosis and spore formation in the yeast Saccharomyces cerevisiae: starvation and the MAT products a1 and alpha 2, which determine the a/alpha cell type. These signals lead to increased expression of the IME1 (inducer of meiosis) gene, which is required for sporulation and sporulation-specific gene expression. We report here the sequence of the IME1 gene and the consequences of IME1 expression from the GAL1 promoter. The deduced IME1 product is a 360-amino-acid protein with a tyrosine-rich C-terminal region. Expression of PGAL1-IME1 in vegetative a/alpha cells led to moderate accumulation of four early sporulation-specific transcripts (IME2, SPO11, SPO13, and HOP1); the transcripts accumulated 3-to 10-fold more after starvation. Two sporulation-specific transcripts normally expressed later (SPS1 and SPS2) did not accumulate until PGAL1-IME1 strains were starved, and the intact IME1 gene was not activated by PGAL1-IME1 expression. In a or alpha cells, which lack alpha 2 or a1, expression of PGAL1-IME1 led to the same pattern of IME2 and SPO13 expression as in a/alpha cells, as measured with ime2::lacZ and spo13::lacZ fusions. Thus, in wild-type strains, the increased expression of IME1 in starved a/alpha cells can account entirely for cell type control, but only partially for nutritional control, of early sporulation-specific gene expression. PGAL1-IME1 expression did not cause growing cells to sporulate but permitted efficient sporulation of amino acid-limited cells, which otherwise sporulated poorly. We suggest that IME1 acts primarily as a positive regulator of early sporulation-specific genes and that growth arrest is an independent prerequisite for execution of the sporulation program."xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.10.12.6103-6113.1990"xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.10.12.6103-6113.1990"xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/author | "Smith H.E."xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/author | "Smith H.E."xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/author | "Mitchell A.P."xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/author | "Mitchell A.P."xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/author | "Neigeborn L."xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/author | "Neigeborn L."xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/author | "Driscoll S.E."xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/author | "Driscoll S.E."xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/author | "Su S.S.Y."xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/author | "Su S.S.Y."xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/pages | "6103-6113"xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/pages | "6103-6113"xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/title | "Role of IME1 expression in regulation of meiosis in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/title | "Role of IME1 expression in regulation of meiosis in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/2247050 | http://purl.uniprot.org/core/volume | "10"xsd:string |