| http://purl.uniprot.org/citations/22472608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22472608 | http://www.w3.org/2000/01/rdf-schema#comment | "Oxygen sensing in hypoxic neurons has been classically attributed to cytochrome c oxidase and prolyl-4-hydroxylases and involves stabilization of transcription factors, hypoxia-inducible factor-1α (Hif-1α) and nuclear factor erythroid 2-related factor 2 (Nrf2) that mediate survival responses. On the contrary, release of cytochrome c into the cytosol during hypoxic stress triggers apoptosis in neuronal cells. We, here advocate that the redox state of neuroglobin (Ngb) could regulate both Hif-1α and Nrf2 stabilization and cytochrome c release during hypoxia. The hippocampal regions showing higher expression of Ngb were less susceptible to global hypoxia-mediated neurodegeneration. During normoxia, Ngb maintained cytochrome c in the reduced state and prevented its release from mitochondria by using cellular antioxidants. Greater turnover of oxidized cytochrome c and increased utilization of cellular antioxidants during acute hypoxia altered cellular redox status and stabilized Hif-1α and Nrf2 through Ngb-mediated mechanism. Chronic hypoxia, however, resulted in oxidation and degradation of Ngb, accumulation of ferric ions and release of cytochrome c that triggered apoptosis. Administration of N-acetyl-cysteine during hypoxic conditions improved neuronal survival by preventing Ngb oxidation and degradation. Taken together, these results establish a role for Ngb in regulating both the survival and apoptotic mechanisms associated with hypoxia."xsd:string |
| http://purl.uniprot.org/citations/22472608 | http://purl.org/dc/terms/identifier | "doi:10.1038/jcbfm.2012.21"xsd:string |
| http://purl.uniprot.org/citations/22472608 | http://purl.uniprot.org/core/author | "Singh S.B."xsd:string |
| http://purl.uniprot.org/citations/22472608 | http://purl.uniprot.org/core/author | "Srivastava R.B."xsd:string |
| http://purl.uniprot.org/citations/22472608 | http://purl.uniprot.org/core/author | "Hota S.K."xsd:string |
| http://purl.uniprot.org/citations/22472608 | http://purl.uniprot.org/core/author | "Hota K.B."xsd:string |
| http://purl.uniprot.org/citations/22472608 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22472608 | http://purl.uniprot.org/core/name | "J Cereb Blood Flow Metab"xsd:string |
| http://purl.uniprot.org/citations/22472608 | http://purl.uniprot.org/core/pages | "1046-1060"xsd:string |
| http://purl.uniprot.org/citations/22472608 | http://purl.uniprot.org/core/title | "Neuroglobin regulates hypoxic response of neuronal cells through Hif-1alpha- and Nrf2-mediated mechanism."xsd:string |
| http://purl.uniprot.org/citations/22472608 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/22472608 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22472608 |
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