| http://purl.uniprot.org/citations/22474288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22474288 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferons are important cytokines that mediate antiviral, antiproliferative, antitumor, and immunoregulatory activities. However, uncontrolled IFN signaling may lead to autoimmune diseases. Here we identified Smurf1 as a negative regulator for IFN-γ signaling by targeting STAT1 for ubiquitination and proteasomal degradation. Smurf1 interacted with STAT1 through the WW domains of Smurf1 and the PY motif in STAT1 and catalyzed K48-linked polyubiquitination of STAT1. Interestingly, the Smurf1-mediated ubiquitination and degradation did not require STAT1 tyrosine and serine phosphorylation. Subsequently, overexpression of Smurf1 attenuated IFN-γ-mediated STAT1 activation and antiviral immune responses, whereas knockdown of Smurf1 enhanced IFN-γ-mediated STAT1 activation, expression of STAT1 target genes, and antiviral immune responses. Furthermore, IFN-γ stimulation led to enhanced expression of Smurf1. Therefore, our results demonstrate that Smurf1 is a negative feedback regulator for IFN-γ signaling by targeting STAT1 for ubiquitination and proteasomal degradation."xsd:string |
| http://purl.uniprot.org/citations/22474288 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.341198"xsd:string |
| http://purl.uniprot.org/citations/22474288 | http://purl.uniprot.org/core/author | "Gao C."xsd:string |
| http://purl.uniprot.org/citations/22474288 | http://purl.uniprot.org/core/author | "Qi J."xsd:string |
| http://purl.uniprot.org/citations/22474288 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/22474288 | http://purl.uniprot.org/core/author | "Yuan C."xsd:string |
| http://purl.uniprot.org/citations/22474288 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22474288 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22474288 | http://purl.uniprot.org/core/pages | "17006-17015"xsd:string |
| http://purl.uniprot.org/citations/22474288 | http://purl.uniprot.org/core/title | "Smurf1 protein negatively regulates interferon-gamma signaling through promoting STAT1 protein ubiquitination and degradation."xsd:string |
| http://purl.uniprot.org/citations/22474288 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/22474288 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22474288 |
| http://purl.uniprot.org/citations/22474288 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22474288 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-22474288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22474288 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUN6-mappedCitation-22474288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22474288 |
| http://purl.uniprot.org/uniprot/#_A8YQE4-mappedCitation-22474288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22474288 |
| http://purl.uniprot.org/uniprot/#_A1Z2M2-mappedCitation-22474288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22474288 |
| http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-22474288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22474288 |
| http://purl.uniprot.org/uniprot/#_P70340-mappedCitation-22474288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22474288 |
| http://purl.uniprot.org/uniprot/#_C4NUL9-mappedCitation-22474288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22474288 |
| http://purl.uniprot.org/uniprot/#_C4NUM1-mappedCitation-22474288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22474288 |
| http://purl.uniprot.org/uniprot/#_E9Q4K9-mappedCitation-22474288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22474288 |
| http://purl.uniprot.org/uniprot/#_E9PYU8-mappedCitation-22474288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22474288 |
| http://purl.uniprot.org/uniprot/#_Q14609-mappedCitation-22474288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22474288 |