| http://purl.uniprot.org/citations/22474389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22474389 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear translocation of cytosolic CLIC4 is an essential feature of its proapoptotic and prodifferentiation functions. Here we demonstrate that CLIC4 is induced concurrently with inducible nitric oxide synthase (iNOS) and S-nitrosylated in proinflammatory peritoneal macrophages. Chemical inhibition or genetic ablation of iNOS inhibits S-nitrosylation and nuclear translocation of CLIC4. In macrophages, iNOS-induced nuclear CLIC4 coincides with the pro-to anti-inflammatory transition of the cells because IL-1β and CXCL1 mRNA remain elevated in CLIC4 and iNOS knockout macrophages at late time points, whereas TNFα mRNA is elevated only in the iNOS knockout macrophages. Active IL-1β remains elevated in CLIC4 knockout macrophages and in macrophages in which CLIC4 nuclear translocation is prevented by the NOS inhibitor l-NAME. Moreover, overexpression of nuclear-targeted CLIC4 down-regulates IL-1β in stimulated macrophages. In mice, genetically null for CLIC4, the number of phagocytosing macrophages stimulated by LPS is reduced. Thus, iNOS-induced nuclear CLIC4 is an essential part of the macrophage deactivation program."xsd:string |
| http://purl.uniprot.org/citations/22474389 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1201351109"xsd:string |
| http://purl.uniprot.org/citations/22474389 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/22474389 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/22474389 | http://purl.uniprot.org/core/author | "Malik M."xsd:string |
| http://purl.uniprot.org/citations/22474389 | http://purl.uniprot.org/core/author | "Howard O.M."xsd:string |
| http://purl.uniprot.org/citations/22474389 | http://purl.uniprot.org/core/author | "Yuspa S.H."xsd:string |
| http://purl.uniprot.org/citations/22474389 | http://purl.uniprot.org/core/author | "Jividen K."xsd:string |
| http://purl.uniprot.org/citations/22474389 | http://purl.uniprot.org/core/author | "Cataisson C."xsd:string |
| http://purl.uniprot.org/citations/22474389 | http://purl.uniprot.org/core/author | "Padmakumar V.C."xsd:string |
| http://purl.uniprot.org/citations/22474389 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22474389 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/22474389 | http://purl.uniprot.org/core/pages | "6130-6135"xsd:string |
| http://purl.uniprot.org/citations/22474389 | http://purl.uniprot.org/core/title | "Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation."xsd:string |
| http://purl.uniprot.org/citations/22474389 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/22474389 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22474389 |
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| http://purl.uniprot.org/uniprot/#_D3YC69-mappedCitation-22474389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22474389 |
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