| http://purl.uniprot.org/citations/22475622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22475622 | http://www.w3.org/2000/01/rdf-schema#comment | "Major depressive disorder (MDD) is accompanied by both cognitive impairments and a hyperactivity of the hypothalamic-pituitary-adrenocortical (HPA) system, resulting in an enhanced glucocorticoid secretion. Cortisol acts via mineralocorticoid and glucocorticoid receptors densely located in the hippocampus, a brain area that is important regarding cognitive functions and especially memory functions. Recently, a variant (rs1545843) affecting transcription of the human SLC6A15 gene has been associated with depression in a genome-wide association study. In an animal model, the neuronal amino acid transporter SLC6A15 was found to be decreased in stress-susceptible mice. Against the background of stress impacting on the activity of the HPA axis, we have investigated alterations of adrenocorticotropic hormone (ACTH) and cortisol secretion in the combined dexamethasone/corticotrophin-releasing hormone (Dex/CRH) test as well as memory and attention performance in a sample of 248 patients with unipolar depression and 172 healthy control subjects genotyped for rs1545843. MDD patients carrying the depression-associated AA genotype showed enhanced maximum and area under the curve ACTH and cortisol answers (p = 0.03) as well as an impaired memory and impaired sustained attention performance (p = 0.04) compared to carriers of at least one G allele. No effects of the SLC6A15 variant were found in the healthy control group. Our findings argue for a role of the SLC6A15 gene in ACTH and cortisol secretion during the Dex/CRH test and furthermore in the occurrence of cognitive impairments in unipolar depression."xsd:string |
| http://purl.uniprot.org/citations/22475622 | http://purl.org/dc/terms/identifier | "doi:10.1017/s1461145712000223"xsd:string |
| http://purl.uniprot.org/citations/22475622 | http://purl.uniprot.org/core/author | "Wagner M."xsd:string |
| http://purl.uniprot.org/citations/22475622 | http://purl.uniprot.org/core/author | "Schuhmacher A."xsd:string |
| http://purl.uniprot.org/citations/22475622 | http://purl.uniprot.org/core/author | "Maier W."xsd:string |
| http://purl.uniprot.org/citations/22475622 | http://purl.uniprot.org/core/author | "Lennertz L."xsd:string |
| http://purl.uniprot.org/citations/22475622 | http://purl.uniprot.org/core/author | "Mossner R."xsd:string |
| http://purl.uniprot.org/citations/22475622 | http://purl.uniprot.org/core/author | "Zobel A."xsd:string |
| http://purl.uniprot.org/citations/22475622 | http://purl.uniprot.org/core/author | "Hofels S."xsd:string |
| http://purl.uniprot.org/citations/22475622 | http://purl.uniprot.org/core/author | "Guttenthaler V."xsd:string |
| http://purl.uniprot.org/citations/22475622 | http://purl.uniprot.org/core/author | "Pfeiffer U."xsd:string |
| http://purl.uniprot.org/citations/22475622 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/22475622 | http://purl.uniprot.org/core/name | "Int J Neuropsychopharmacol"xsd:string |
| http://purl.uniprot.org/citations/22475622 | http://purl.uniprot.org/core/pages | "83-90"xsd:string |
| http://purl.uniprot.org/citations/22475622 | http://purl.uniprot.org/core/title | "A variant of the neuronal amino acid transporter SLC6A15 is associated with ACTH and cortisol responses and cognitive performance in unipolar depression."xsd:string |
| http://purl.uniprot.org/citations/22475622 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/22475622 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22475622 |
| http://purl.uniprot.org/citations/22475622 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22475622 |
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| http://purl.uniprot.org/uniprot/#_Q9NW50-mappedCitation-22475622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22475622 |