| http://purl.uniprot.org/citations/22479480 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22479480 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundHIV-1 replication depends on a delicate balance between cellular co-factors and antiviral restriction factors. Lens epithelium-derived growth factor (LEDGF/p75) benefits HIV, whereas apolipoprotein B mRNA-editing catalytic polypeptide-like 3G (APOBEC3G), tripartite motif 5alpha (TRIM5α), and tetherin exert anti-HIV activity. Expression levels of these proteins possibly contribute to HIV-1 resistance in HIV-1-exposed populations.Methodology/principal findingsWe used real-time PCR and flow cytometry to study mRNA and protein levels respectively in PBMC and PBMC subsets. We observed significantly reduced LEDGF/p75 protein levels in CD4+ lymphocytes of HIV-1-exposed seronegative subjects relative to healthy controls, whereas we found no differences in APOBEC3G, TRIM5α, or tetherin expression. Untreated HIV-1-infected patients generally expressed higher mRNA and protein levels than healthy controls. Increased tetherin levels, in particular, correlated with markers of disease progression: directly with the viral load and T cell activation and inversely with the CD4 count.Conclusions/significanceOur data suggest that reduced LEDGF/p75 levels may play a role in resistance to HIV-1 infection, while increased tetherin levels could be a marker of advanced HIV disease. Host factors that influence HIV-1 infection and disease could be important targets for new antiviral therapies."xsd:string |
| http://purl.uniprot.org/citations/22479480 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0033934"xsd:string |
| http://purl.uniprot.org/citations/22479480 | http://purl.uniprot.org/core/author | "Mboup S."xsd:string |
| http://purl.uniprot.org/citations/22479480 | http://purl.uniprot.org/core/author | "Kestens L."xsd:string |
| http://purl.uniprot.org/citations/22479480 | http://purl.uniprot.org/core/author | "Camara M."xsd:string |
| http://purl.uniprot.org/citations/22479480 | http://purl.uniprot.org/core/author | "Seydi M."xsd:string |
| http://purl.uniprot.org/citations/22479480 | http://purl.uniprot.org/core/author | "Jennes W."xsd:string |
| http://purl.uniprot.org/citations/22479480 | http://purl.uniprot.org/core/author | "Daneau G."xsd:string |
| http://purl.uniprot.org/citations/22479480 | http://purl.uniprot.org/core/author | "Van Ostade X."xsd:string |
| http://purl.uniprot.org/citations/22479480 | http://purl.uniprot.org/core/author | "Mous K."xsd:string |
| http://purl.uniprot.org/citations/22479480 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22479480 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22479480 | http://purl.uniprot.org/core/pages | "e33934"xsd:string |
| http://purl.uniprot.org/citations/22479480 | http://purl.uniprot.org/core/title | "Expression analysis of LEDGF/p75, APOBEC3G, TRIM5alpha, and tetherin in a Senegalese cohort of HIV-1-exposed seronegative individuals."xsd:string |
| http://purl.uniprot.org/citations/22479480 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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