| http://purl.uniprot.org/citations/22479519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22479519 | http://www.w3.org/2000/01/rdf-schema#comment | "An imbalance between pro-survival and pro-death pathways in brain cells can lead to neuronal cell death and neurodegeneration. While such imbalance is known to be associated with alterations in glutamatergic and Ca(2+) signaling, the underlying mechanisms remain undefined. We identified the protein Ser/Thr phosphatase protein phosphatase-1 (PP1), an enzyme associated with glutamate receptors, as a key trigger of survival pathways that can prevent neuronal death and neurodegeneration in the adult hippocampus. We show that PP1α overexpression in hippocampal neurons limits NMDA receptor overactivation and Ca(2+) overload during an excitotoxic event, while PP1 inhibition favors Ca(2+) overload and cell death. The protective effect of PP1 is associated with a selective dephosphorylation on a residue phosphorylated by CaMKIIα on the NMDA receptor subunit NR2B, which promotes pro-survival pathways and associated transcriptional programs. These results reveal a novel contributor to the mechanisms of neuroprotection and underscore the importance of PP1-dependent dephosphorylation in these mechanisms. They provide a new target for the development of potential therapeutic treatment of neurodegeneration."xsd:string |
| http://purl.uniprot.org/citations/22479519 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0034047"xsd:string |
| http://purl.uniprot.org/citations/22479519 | http://purl.uniprot.org/core/author | "Mansuy I.M."xsd:string |
| http://purl.uniprot.org/citations/22479519 | http://purl.uniprot.org/core/author | "Tyagarajan S.K."xsd:string |
| http://purl.uniprot.org/citations/22479519 | http://purl.uniprot.org/core/author | "Farinelli M."xsd:string |
| http://purl.uniprot.org/citations/22479519 | http://purl.uniprot.org/core/author | "Heitz F.D."xsd:string |
| http://purl.uniprot.org/citations/22479519 | http://purl.uniprot.org/core/author | "Grewe B.F."xsd:string |
| http://purl.uniprot.org/citations/22479519 | http://purl.uniprot.org/core/author | "Helmchen F."xsd:string |
| http://purl.uniprot.org/citations/22479519 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22479519 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22479519 | http://purl.uniprot.org/core/pages | "e34047"xsd:string |
| http://purl.uniprot.org/citations/22479519 | http://purl.uniprot.org/core/title | "Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection."xsd:string |
| http://purl.uniprot.org/citations/22479519 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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