http://purl.uniprot.org/citations/22482402 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/22482402 | http://www.w3.org/2000/01/rdf-schema#comment | "AimTo investigate the effect of TFDP3 on prostate cancer cell line LNCaP by transgenic method, and to explore the effect of TFDP3 on regulating the autophay and apoptosis by co-regulation with E2F1.MethodsLNCaP cells were transfected with pcDNA3.1-TFDP3, pCMV-E2F1-HA or pcDNA3.1 empty vector.The expression of TFDP3, E2F1 and LC3B were detected by real-time PCR after transfection for 24 h. Western blotting was used to monitor the changes in autophagy-associated protein LC3B, Apoptosis of transfected cells were analyzed by flow cytometry.ResultsThe results showed that activation of TFDP3 upregulates the expression of autophagy genes-microtubule-associated protein-1 light chain-3B (LC3B), and E2F1 antagonizes TFDP3-induced autophagy, and TFDP3 can inhibit E2F1-induced apoptosis.ConclusionTFDP3 upregulates the expression of autophagy gene LC3B and inhibits E2F1-induced apoptosis, and may play an important role in prostate cancer."xsd:string |
http://purl.uniprot.org/citations/22482402 | http://purl.uniprot.org/core/author | "Ma Y.Y."xsd:string |
http://purl.uniprot.org/citations/22482402 | http://purl.uniprot.org/core/author | "Hao X.K."xsd:string |
http://purl.uniprot.org/citations/22482402 | http://purl.uniprot.org/core/author | "Su M.Q."xsd:string |
http://purl.uniprot.org/citations/22482402 | http://purl.uniprot.org/core/author | "Ren L.F."xsd:string |
http://purl.uniprot.org/citations/22482402 | http://purl.uniprot.org/core/author | "Yue Q.H."xsd:string |
http://purl.uniprot.org/citations/22482402 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
http://purl.uniprot.org/citations/22482402 | http://purl.uniprot.org/core/name | "Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"xsd:string |
http://purl.uniprot.org/citations/22482402 | http://purl.uniprot.org/core/pages | "347-349"xsd:string |
http://purl.uniprot.org/citations/22482402 | http://purl.uniprot.org/core/title | "[Effects of TFDP3 on regulating the autophagy and apoptosis of LNCaP cells]."xsd:string |
http://purl.uniprot.org/citations/22482402 | http://purl.uniprot.org/core/volume | "28"xsd:string |
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