| http://purl.uniprot.org/citations/22483108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22483108 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22483108 | http://www.w3.org/2000/01/rdf-schema#comment | "The viral oncoprotein E6 is an essential factor for cervical cancers induced by "high-risk" mucosal HPV. Among other oncogenic activities, E6 recruits the ubiquitin ligase E6AP to promote the ubiquitination and subsequent proteasomal degradation of p53. E6 is prone to self-association, which long precluded its structural analysis. Here we found that E6 specifically dimerizes through its N-terminal domain and that disruption of the dimer interface strongly increases E6 solubility. This allowed us to raise structural data covering the entire HPV16 E6 protein, including the high-resolution NMR structures of the two zinc-binding domains of E6 and a robust data-driven model structure of the N-terminal domain homodimer. Interestingly, homodimer interface mutations that disrupt E6 self-association also inactivate E6-mediated p53 degradation. These data suggest that E6 needs to self-associate via its N-terminal domain to promote the polyubiquitination of p53 by E6AP."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2012.02.001"xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2012.02.001"xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/author | "Atkinson A."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/author | "Atkinson A."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/author | "Rybin V."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/author | "Rybin V."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/author | "Kieffer B."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/author | "Kieffer B."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/author | "Boulade-Ladame C."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/author | "Boulade-Ladame C."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/author | "Chappelle A."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/author | "Chappelle A."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/author | "Trave G."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/author | "Trave G."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/author | "Zanier K."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/author | "Zanier K."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/author | "ould M'hamed ould Sidi A."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/author | "ould M'hamed ould Sidi A."xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/22483108 | http://purl.uniprot.org/core/name | "Structure"xsd:string |