| http://purl.uniprot.org/citations/22483852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22483852 | http://www.w3.org/2000/01/rdf-schema#comment | "Hlx as a Th1-specific transcription factor, it appears to drive maturation of Th1 and IFN-γ secretion in cooperation with T-bet. In this study, we established a stable Hlx-over-expressed dendritic cell line (DC2.4/Hlx), and investigated the possible effect of Hlx gene on maturation of dendritic cell-line (DC2.4). Results shown that over-expressed Hlx in DC2.4 up-regulated the transcription and expression of IFN-γ, increased the expression of maturation makers including CD40, CD80, CD86, MHC-I and MHC-II. Functional assay for DC2.4/Hlx showed that over-expressed Hlx increased the expression level of interleukin-12 in the supernatant and decreased DC endocytosis when cells were incubated in vitro. Furthermore, using a syngeneic T cell activation model, we found that DC2.4/Hlx could obviously present ovalbumin (OVA) antigen to T cell in OVA pre-immunized mice."xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellimm.2012.02.016"xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/author | "He Z."xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/author | "Lu L."xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/author | "Sun Q."xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/author | "Su Z."xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/author | "Xue Y."xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/author | "Shao Q."xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/author | "Zheng D."xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/author | "Shotorbani S.S."xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/name | "Cell Immunol"xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/pages | "61-68"xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/title | "Over-expression of Hlx homeobox gene in DC2.4 dendritic cell enhances its maturation and antigen presentation."xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://purl.uniprot.org/core/volume | "275"xsd:string |
| http://purl.uniprot.org/citations/22483852 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22483852 |
| http://purl.uniprot.org/citations/22483852 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22483852 |
| http://purl.uniprot.org/uniprot/#_G3V024-mappedCitation-22483852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22483852 |
| http://purl.uniprot.org/uniprot/#_Q80YV1-mappedCitation-22483852 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22483852 |