| http://purl.uniprot.org/citations/22486887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22486887 | http://www.w3.org/2000/01/rdf-schema#comment | "Bulk flow constitutes a substantial part of the slow transport of soluble proteins in axons. Though the underlying mechanism is unclear, evidences indicate that intermittent, kinesin-based movement of large protein-aggregates aids this process. Choline acetyltransferase (ChAT), a soluble enzyme catalyzing acetylcholine synthesis, propagates toward the synapse at an intermediate, slow rate. The presynaptic enrichment of ChAT requires heterotrimeric kinesin-2, comprising KLP64D, KLP68D and DmKAP, in Drosophila. Here, we show that the bulk flow of a recombinant Green Fluorescent Protein-tagged ChAT (GFP::ChAT), in Drosophila axons, lacks particulate features. It occurs for a brief period during the larval stages. In addition, both the endogenous ChAT and GFP::ChAT directly bind to the KLP64D tail, which is essential for the GFP::ChAT entry and anterograde flow in axon. These evidences suggest that a direct interaction with motor proteins could regulate the bulk flow of soluble proteins, and thus establish their asymmetric distribution."xsd:string |
| http://purl.uniprot.org/citations/22486887 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-0854.2012.01361.x"xsd:string |
| http://purl.uniprot.org/citations/22486887 | http://purl.uniprot.org/core/author | "Hamid R."xsd:string |
| http://purl.uniprot.org/citations/22486887 | http://purl.uniprot.org/core/author | "Ray K."xsd:string |
| http://purl.uniprot.org/citations/22486887 | http://purl.uniprot.org/core/author | "Ghosal D."xsd:string |
| http://purl.uniprot.org/citations/22486887 | http://purl.uniprot.org/core/author | "Jana S.C."xsd:string |
| http://purl.uniprot.org/citations/22486887 | http://purl.uniprot.org/core/author | "Doodhi H."xsd:string |
| http://purl.uniprot.org/citations/22486887 | http://purl.uniprot.org/core/author | "Girotra M."xsd:string |
| http://purl.uniprot.org/citations/22486887 | http://purl.uniprot.org/core/author | "Sadananda A."xsd:string |
| http://purl.uniprot.org/citations/22486887 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22486887 | http://purl.uniprot.org/core/name | "Traffic"xsd:string |
| http://purl.uniprot.org/citations/22486887 | http://purl.uniprot.org/core/pages | "979-991"xsd:string |
| http://purl.uniprot.org/citations/22486887 | http://purl.uniprot.org/core/title | "Interaction with a kinesin-2 tail propels choline acetyltransferase flow towards synapse."xsd:string |
| http://purl.uniprot.org/citations/22486887 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/22486887 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22486887 |
| http://purl.uniprot.org/citations/22486887 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22486887 |
| http://purl.uniprot.org/uniprot/#_B7Z139-mappedCitation-22486887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22486887 |
| http://purl.uniprot.org/uniprot/#_A8JUR4-mappedCitation-22486887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22486887 |
| http://purl.uniprot.org/uniprot/#_A8JUR5-mappedCitation-22486887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22486887 |
| http://purl.uniprot.org/uniprot/#_M9PF68-mappedCitation-22486887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22486887 |
| http://purl.uniprot.org/uniprot/#_M9PGF6-mappedCitation-22486887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22486887 |
| http://purl.uniprot.org/uniprot/#_M9PGW1-mappedCitation-22486887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22486887 |
| http://purl.uniprot.org/uniprot/#_P07668-mappedCitation-22486887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22486887 |
| http://purl.uniprot.org/uniprot/#_P34082-mappedCitation-22486887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22486887 |