| http://purl.uniprot.org/citations/22487795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22487795 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondria play a critical role in regulation of apoptosis, a form of programmed cell death, by releasing apoptogenic factors including cytochrome c. Growing evidence suggests that dynamic changes in mitochondrial morphology are involved in cellular apoptotic response. However, whether DRP1-mediated mitochondrial fission is required for induction of apoptosis remains speculative. Here, we show that siRNA-mediated DRP1 knockdown promoted accumulation of elongated mitochondria in HCT116 and SW480 human colon cancer cells. Surprisingly, DRP1 down-regulation led to decreased proliferation and increased apoptosis of these cells. A higher rate of cytochrome c release and reductions in mitochondrial membrane potential were also revealed in DRP1-depleted cells. Taken together, our present findings suggest that mitochondrial fission factor DRP1 inhibits colon cancer cell apoptosis through the regulation of cytochrome c release and mitochondrial membrane integrity."xsd:string |
| http://purl.uniprot.org/citations/22487795 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2012.03.118"xsd:string |
| http://purl.uniprot.org/citations/22487795 | http://purl.uniprot.org/core/author | "Oda H."xsd:string |
| http://purl.uniprot.org/citations/22487795 | http://purl.uniprot.org/core/author | "Inoue-Yamauchi A."xsd:string |
| http://purl.uniprot.org/citations/22487795 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22487795 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/22487795 | http://purl.uniprot.org/core/pages | "81-85"xsd:string |
| http://purl.uniprot.org/citations/22487795 | http://purl.uniprot.org/core/title | "Depletion of mitochondrial fission factor DRP1 causes increased apoptosis in human colon cancer cells."xsd:string |
| http://purl.uniprot.org/citations/22487795 | http://purl.uniprot.org/core/volume | "421"xsd:string |
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