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http://purl.uniprot.org/citations/22490650http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22490650http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To explore the effects of mifepristone on the expressions of HLA-G, HLA-E and HLA-F in extravillous cytotrophoblasts (EVCT).

Methods

Cultured EVCT during the first trimester were treated in vitro with progesterone and mifepristone. And the transcription levels of HLA-G, HLA-E and HLA-F genes were detected by RT-PCR (reverse transcription-polymerase chain reaction).

Results

As compared with the controls, the levels of HLA-G, HLA-E and HLA-F mRNA significantly increased in EVCT after incubating with 0.1 ng/L progesterone (P < 0.05). These effects could be completely blocked by a co-incubation with mifepristone at the same concentrations.

Conclusion

Mifepristone can inhibit the effects of progesterone by down-regulating the expressions of HLA-G, HLA-E and HLA-F mRNA in trophoblasts during the first trimester."xsd:string
http://purl.uniprot.org/citations/22490650http://purl.uniprot.org/core/author"Wang Y."xsd:string
http://purl.uniprot.org/citations/22490650http://purl.uniprot.org/core/author"Zhang Y."xsd:string
http://purl.uniprot.org/citations/22490650http://purl.uniprot.org/core/author"Zeng B."xsd:string
http://purl.uniprot.org/citations/22490650http://purl.uniprot.org/core/author"Liao A.H."xsd:string
http://purl.uniprot.org/citations/22490650http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22490650http://purl.uniprot.org/core/name"Zhonghua Yi Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/22490650http://purl.uniprot.org/core/pages"15-17"xsd:string
http://purl.uniprot.org/citations/22490650http://purl.uniprot.org/core/title"[Mifepristone inhibits the progesterone-induced expressions of HLA-G, -E, -F genes in trophoblasts during first trimester]."xsd:string
http://purl.uniprot.org/citations/22490650http://purl.uniprot.org/core/volume"92"xsd:string
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