| http://purl.uniprot.org/citations/22490863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22490863 | http://www.w3.org/2000/01/rdf-schema#comment | "The cosignaling network mediated by the herpesvirus entry mediator (HVEM; TNFRSF14) functions as a dual directional system that involves proinflammatory ligand, lymphotoxin that exhibits inducible expression and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes (LIGHT; TNFSF14), and the inhibitory Ig family member B and T lymphocyte attenuator (BTLA). To dissect the differential contributions of HVEM/BTLA and HVEM/LIGHT interactions, topographically-specific, competitive, and nonblocking anti-HVEM Abs that inhibit BTLA binding, but not LIGHT, were developed. We demonstrate that a BTLA-specific competitor attenuated the course of acute graft-versus-host reaction in a murine F(1) transfer semiallogeneic model. Selective HVEM/BTLA blockade did not inhibit donor T cell infiltration into graft-versus-host reaction target organs, but decreased the functional activity of the alloreactive T cells. These results highlight the critical role of HVEM/BTLA pathway in the control of the allogeneic immune response and identify a new therapeutic target for transplantation and autoimmune diseases."xsd:string |
| http://purl.uniprot.org/citations/22490863 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1103698"xsd:string |
| http://purl.uniprot.org/citations/22490863 | http://purl.uniprot.org/core/author | "Ware C.F."xsd:string |
| http://purl.uniprot.org/citations/22490863 | http://purl.uniprot.org/core/author | "Shintani Y."xsd:string |
| http://purl.uniprot.org/citations/22490863 | http://purl.uniprot.org/core/author | "Norris P."xsd:string |
| http://purl.uniprot.org/citations/22490863 | http://purl.uniprot.org/core/author | "Jones N.D."xsd:string |
| http://purl.uniprot.org/citations/22490863 | http://purl.uniprot.org/core/author | "Rodriguez-Barbosa J.I."xsd:string |
| http://purl.uniprot.org/citations/22490863 | http://purl.uniprot.org/core/author | "del Rio M.L."xsd:string |
| http://purl.uniprot.org/citations/22490863 | http://purl.uniprot.org/core/author | "Buhler L."xsd:string |
| http://purl.uniprot.org/citations/22490863 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22490863 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22490863 | http://purl.uniprot.org/core/pages | "4885-4896"xsd:string |
| http://purl.uniprot.org/citations/22490863 | http://purl.uniprot.org/core/title | "Selective blockade of herpesvirus entry mediator-B and T lymphocyte attenuator pathway ameliorates acute graft-versus-host reaction."xsd:string |
| http://purl.uniprot.org/citations/22490863 | http://purl.uniprot.org/core/volume | "188"xsd:string |
| http://purl.uniprot.org/citations/22490863 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22490863 |
| http://purl.uniprot.org/citations/22490863 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22490863 |
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