| http://purl.uniprot.org/citations/22490869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22490869 | http://www.w3.org/2000/01/rdf-schema#comment | "Tight regulation of MHC class I gene expression is critical for CD8 T cell activation and host adaptive-immune responses. The promoters of MHC class I genes contain a well-conserved core module, the W/S-X-Y motif, which assembles a nucleoprotein complex termed MHC enhanceosome. A member of the nucleotide-binding domain, leucine-rich repeat (NLR) protein family, NLRC5, is a newly identified transcriptional regulator of MHC class I genes. NLRC5 associates with and transactivates the proximal promoters of MHC class I genes, although the molecular mechanism of transactivation has not been understood. In this article, we show that NLRC5-mediated MHC class I gene induction requires the W/S and X1, X2 cis-regulatory elements. The transcription factors RFX5, RFXAP, and RFXANK/B, which compose the RFX protein complex and associate with the X1 box, cooperate with NLRC5 for MHC class I expression. Coimmunoprecipitation experiments revealed that NLRC5 specifically interacts with the RFX subunit RFXANK/B via its ankyrin repeats. In addition, we show that NLRC5 can cooperate with ATF1 and the transcriptional coactivators CBP/p300 and general control nonderepressible 5, which display histone acetyltransferase activity. Taken together, our data suggest that NLRC5 participates in an MHC class I-specific enhanceosome, which assembles on the conserved W/S-X-Y core module of the MHC class I proximal promoters, including the RFX factor components and CREB/ATF1 family transcription factors, to promote MHC class I gene expression."xsd:string |
| http://purl.uniprot.org/citations/22490869 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1103160"xsd:string |
| http://purl.uniprot.org/citations/22490869 | http://purl.uniprot.org/core/author | "Biswas A."xsd:string |
| http://purl.uniprot.org/citations/22490869 | http://purl.uniprot.org/core/author | "Li A."xsd:string |
| http://purl.uniprot.org/citations/22490869 | http://purl.uniprot.org/core/author | "Lee K.H."xsd:string |
| http://purl.uniprot.org/citations/22490869 | http://purl.uniprot.org/core/author | "van den Elsen P.J."xsd:string |
| http://purl.uniprot.org/citations/22490869 | http://purl.uniprot.org/core/author | "Liu Y.J."xsd:string |
| http://purl.uniprot.org/citations/22490869 | http://purl.uniprot.org/core/author | "Kobayashi K.S."xsd:string |
| http://purl.uniprot.org/citations/22490869 | http://purl.uniprot.org/core/author | "van Eggermond M.C."xsd:string |
| http://purl.uniprot.org/citations/22490869 | http://purl.uniprot.org/core/author | "Meissner T.B."xsd:string |
| http://purl.uniprot.org/citations/22490869 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22490869 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22490869 | http://purl.uniprot.org/core/pages | "4951-4958"xsd:string |
| http://purl.uniprot.org/citations/22490869 | http://purl.uniprot.org/core/title | "NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression."xsd:string |
| http://purl.uniprot.org/citations/22490869 | http://purl.uniprot.org/core/volume | "188"xsd:string |
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