| http://purl.uniprot.org/citations/22491943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22491943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22491943 | http://www.w3.org/2000/01/rdf-schema#comment | "In bilateria, positioning and looping of visceral organs requires proper left-right (L/R) asymmetry establishment. Recent work in Drosophila has identified a novel situs inversus gene encoding the unconventional type ID myosin (MyoID). In myoID mutant flies, the L/R axis is inverted, causing reversed looping of organs, such as the gut, spermiduct and genitalia. We have previously shown that MyoID interacts physically with β-Catenin, suggesting a role of the adherens junction in Drosophila L/R asymmetry. Here, we show that DE-Cadherin co-immunoprecipitates with MyoID and is required for MyoID L/R activity. We further demonstrate that MyoIC, a closely related unconventional type I myosin, can antagonize MyoID L/R activity by preventing its binding to adherens junction components, both in vitro and in vivo. Interestingly, DE-Cadherin inhibits MyoIC, providing a protective mechanism to MyoID function. Conditional genetic experiments indicate that DE-Cadherin, MyoIC and MyoID show temporal synchronicity for their function in L/R asymmetry. These data suggest that following MyoID recruitment by β-Catenin at the adherens junction, DE-Cadherin has a twofold effect on Drosophila L/R asymmetry by promoting MyoID activity and repressing that of MyoIC. Interestingly, the product of the vertebrate situs inversus gene inversin also physically interacts with β-Catenin, suggesting that the adherens junction might serve as a conserved platform for determinants to establish L/R asymmetry both in vertebrates and invertebrates."xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.047589"xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.047589"xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/author | "Petzoldt A.G."xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/author | "Petzoldt A.G."xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/author | "Cerezo D."xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/author | "Cerezo D."xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/author | "Coutelis J.B."xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/author | "Coutelis J.B."xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/author | "Geminard C."xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/author | "Geminard C."xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/author | "Noselli S."xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/author | "Noselli S."xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/author | "Speder P."xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/author | "Speder P."xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/author | "Suzanne M."xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/author | "Suzanne M."xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/pages | "1874-1884"xsd:string |
| http://purl.uniprot.org/citations/22491943 | http://purl.uniprot.org/core/pages | "1874-1884"xsd:string |