| http://purl.uniprot.org/citations/22496224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22496224 | http://www.w3.org/2000/01/rdf-schema#comment | "Variants near the HLA-DP gene show the strongest genome-wide association with chronic hepatitis B virus (HBV) infection and HBV recovery/persistence in Asians. To test the effect of the HLA-DP region on outcomes to HBV infection, we sequenced the polymorphic HLA-DPB1 and DPA1 coding exons and the corresponding 3' untranslated regions (3'UTRs) in 662 individuals of European-American and African-American ancestry. The genome-wide association study (GWAS) variant (rs9277535; 550A/G) in the 3'UTR of the HLA-DPB1 gene that associated most significantly with chronic hepatitis B and outcomes to HBV infection in Asians had a marginal effect on HBV recovery in our European- and African-American samples (odds ratio [OR] = 0.39, P = 0.01, combined ethnic groups). However, we identified a novel variant in the HLA-DPB1 3'UTR region, 496A/G (rs9277534), which associated very significantly with HBV recovery in both European and African-American populations (OR = 0.37, P = 0.0001, combined ethnic groups). The 496A/G variant distinguishes the most protective HLA-DPB1 allele (DPB1*04:01) from the most susceptible (DPB1*01:01), whereas 550A/G does not. 496A/G has a stronger effect than any individual HLA-DPB1 or DPA1 allele and any other HLA alleles that showed an association with HBV recovery in our European-American cohort. The 496GG genotype, which confers recessive susceptibility to HBV persistence, also associates in a recessive manner with significantly higher levels of HLA-DP surface protein and transcript level expression in healthy donors, suggesting that differences in expression of HLA-DP may increase the risk of persistent HBV infection."xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.00406-12"xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/author | "Carrington M."xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/author | "Gao X."xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/author | "Qi Y."xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/author | "Stein J.L."xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/author | "Thomas R."xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/author | "Goedert J.J."xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/author | "Thio C.L."xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/author | "Apps R."xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/author | "Wolinsky S."xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/author | "Kirk G.D."xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/author | "Marti D."xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/author | "Moody M.A."xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/author | "Soderberg K.A."xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/author | "Hoots W.K."xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/pages | "6979-6985"xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/title | "A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection."xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/22496224 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22496224 |
| http://purl.uniprot.org/citations/22496224 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22496224 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C545-mappedCitation-22496224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22496224 |