| http://purl.uniprot.org/citations/22496542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22496542 | http://www.w3.org/2000/01/rdf-schema#comment | "Dermatan sulfate epimerase 2 (DS-epi2), together with its homolog DS-epi1, transform glucuronic acid into iduronic acid in DS polysaccharide chains. Iduronic acid gives DS increased chain flexibility and promotes protein binding. DS-epi2 is ubiquitously expressed and is the predominant epimerase in the brain. Here, we report the generation and initial characterization of DS-epi2 null mice. DS-epi2-deficient mice showed no anatomical, histological or morphological abnormalities. The body weights and lengths of mutated and wild-type littermates were indistinguishable. They were fertile and had a normal lifespan. Chondroitin sulfate (CS)/DS isolated from the newborn mutated mouse brains had a 38% reduction in iduronic acid compared with wild-type littermates, and compositional analysis revealed a decrease in 4-O-sulfate and an increase in 6-O-sulfate containing structures. Despite the reduction in iduronic acid, the adult DS-epi2-/-brain showed normal extracellular matrix features by immunohistological stainings. We conclude that DS-epi1 compensates in vivo for the loss of DS-epi2. These results extend previous findings of the functional redundancy of brain extracellular matrix components."xsd:string |
| http://purl.uniprot.org/citations/22496542 | http://purl.org/dc/terms/identifier | "doi:10.1093/glycob/cws065"xsd:string |
| http://purl.uniprot.org/citations/22496542 | http://purl.uniprot.org/core/author | "Bartolini B."xsd:string |
| http://purl.uniprot.org/citations/22496542 | http://purl.uniprot.org/core/author | "Oldberg A."xsd:string |
| http://purl.uniprot.org/citations/22496542 | http://purl.uniprot.org/core/author | "Maccarana M."xsd:string |
| http://purl.uniprot.org/citations/22496542 | http://purl.uniprot.org/core/author | "Malmstrom A."xsd:string |
| http://purl.uniprot.org/citations/22496542 | http://purl.uniprot.org/core/author | "Rauch U."xsd:string |
| http://purl.uniprot.org/citations/22496542 | http://purl.uniprot.org/core/author | "Feinstein R."xsd:string |
| http://purl.uniprot.org/citations/22496542 | http://purl.uniprot.org/core/author | "Thelin M.A."xsd:string |
| http://purl.uniprot.org/citations/22496542 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22496542 | http://purl.uniprot.org/core/name | "Glycobiology"xsd:string |
| http://purl.uniprot.org/citations/22496542 | http://purl.uniprot.org/core/pages | "1007-1016"xsd:string |
| http://purl.uniprot.org/citations/22496542 | http://purl.uniprot.org/core/title | "Mouse development is not obviously affected by the absence of dermatan sulfate epimerase 2 in spite of a modified brain dermatan sulfate composition."xsd:string |
| http://purl.uniprot.org/citations/22496542 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/22496542 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22496542 |
| http://purl.uniprot.org/citations/22496542 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22496542 |
| http://purl.uniprot.org/uniprot/Q0VBN2#attribution-B8B8867585D2A53C21D85DCD9EB1CA5D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22496542 |
| http://purl.uniprot.org/uniprot/#_Q0VBN2-mappedCitation-22496542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22496542 |
| http://purl.uniprot.org/uniprot/#_Q8BZP3-mappedCitation-22496542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22496542 |
| http://purl.uniprot.org/uniprot/Q0VBN2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22496542 |
| http://purl.uniprot.org/uniprot/Q8BZP3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22496542 |