| http://purl.uniprot.org/citations/2249759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2249759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2249759 | http://www.w3.org/2000/01/rdf-schema#comment | "We describe interactions between maternal-effect lethal mutations in four genes of Caenorhabditis elegans whose products appear to be involved in the meiotic and mitotic divisions of the one-cell embryo. Mitosis is disrupted by two dominant temperature-sensitive gain-of-function maternal-effect lethal mutations, mei-1(ct46) and mel-26(ct61), and by recessive loss-of-function maternal-effect lethal mutations of zyg-9. The phenotypic defects resulting from these mutations are similar. Doubly mutant combinations show a strong enhancement of the maternal-effect lethality under semipermissive conditions, suggesting that the mutant gene products interact. We isolated 15 dominant suppressors of the gain-of-function mutation mei-1(ct46). Thirteen of these suppressors are apparently intragenic, but 11 of them suppress in trans as well as cis. Two extragenic suppressors define a new gene, mei-2. The suppressor mutations in these two genes also result in recessive maternal-effect lethality, but with meiotic rather than mitotic defects. Surprisingly, most of these suppressors are also able to suppress mel-26(ct61) in addition to mei-1(ct46). The products of the four genes mei-1, mei-2, zyg-9 and mel-26 could be responsible for some of the specialized features that distinguish the meiotic from the mitotic divisions in the one-cell embryo."xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/126.3.593"xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/126.3.593"xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/author | "Wood W.B."xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/author | "Wood W.B."xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/author | "Mains P.E."xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/author | "Mains P.E."xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/author | "Kemphues K.J."xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/author | "Kemphues K.J."xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/author | "Sprunger S.A."xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/author | "Sprunger S.A."xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/author | "Sulston I.A."xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/author | "Sulston I.A."xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/pages | "593-605"xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/pages | "593-605"xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/title | "Mutations affecting the meiotic and mitotic divisions of the early Caenorhabditis elegans embryo."xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/title | "Mutations affecting the meiotic and mitotic divisions of the early Caenorhabditis elegans embryo."xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/2249759 | http://purl.uniprot.org/core/volume | "126"xsd:string |