| http://purl.uniprot.org/citations/2249881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2249881 | http://www.w3.org/2000/01/rdf-schema#comment | "Susceptibility to autoimmune orchitis is associated with an immune response (Ir) gene (now designated Orch-1) which was preliminarily shown to reside at or near the H-2D subregion of the major histocompatibility complex in the mouse (H-2). In this study, the role of H-2 in controlling both disease susceptibility and the phenotypic expression of infertility associated with autoimmune orchitis has been significantly extended. Of nine C57BL/10SnJ and three BALB/cAnN H-2 congenic strains, only those mice possessing the H-2d, H-2p haplotypes exhibited autoimmune orchitis accompanied by infertility. All other congenic strains, including those expressing the H-2 haplotypes v, q, b, s, r, f, and k were of the low responder phenotype. In addition, disease susceptibility was found to be inherited as a dominant trait in H-2 congenic F1 hybrid mice. In order to map the precise location of the Orch-1 locus within H-2, 32 intra-H-2 recombinant congenic strains possessing defined crossovers in various locations throughout the H-2 region were studied. The results of the analysis indicate that Orch-1 maps within the interval between the H-2S and H-2D regions. Our results also indicate that class II genes, i.e., A and E region-encoded genes, have little discernable effect in controlling disease susceptibility and resistance despite the fact that testicular lesions can be adoptively transferred with Ia-restricted CD4+ effector T cells. A comparison of the Orch-1 alleles with the genotypes of two additional markers which map within the H-2S/H-2D interval suggests the following gene order: H-2S--TNP-Ficoll--Orch-1--Tnfa--H-2D."xsd:string |
| http://purl.uniprot.org/citations/2249881 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf00211648"xsd:string |
| http://purl.uniprot.org/citations/2249881 | http://purl.uniprot.org/core/author | "Woodward S.R."xsd:string |
| http://purl.uniprot.org/citations/2249881 | http://purl.uniprot.org/core/author | "Teuscher C."xsd:string |
| http://purl.uniprot.org/citations/2249881 | http://purl.uniprot.org/core/author | "Gasser D.L."xsd:string |
| http://purl.uniprot.org/citations/2249881 | http://purl.uniprot.org/core/author | "Hickey W.F."xsd:string |
| http://purl.uniprot.org/citations/2249881 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2249881 | http://purl.uniprot.org/core/name | "Immunogenetics"xsd:string |
| http://purl.uniprot.org/citations/2249881 | http://purl.uniprot.org/core/pages | "337-344"xsd:string |
| http://purl.uniprot.org/citations/2249881 | http://purl.uniprot.org/core/title | "Experimental allergic orchitis in mice. VI. Recombinations within the H-2S/H-2D interval define the map position of the H-2-associated locus controlling disease susceptibility."xsd:string |
| http://purl.uniprot.org/citations/2249881 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/2249881 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2249881 |
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| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-2249881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2249881 |
| http://purl.uniprot.org/uniprot/#_A0A482D1Q0-mappedCitation-2249881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2249881 |
| http://purl.uniprot.org/uniprot/#_G3UZP7-mappedCitation-2249881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2249881 |
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| http://purl.uniprot.org/uniprot/#_Q31154-mappedCitation-2249881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2249881 |
| http://purl.uniprot.org/uniprot/#_Q31167-mappedCitation-2249881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2249881 |
| http://purl.uniprot.org/uniprot/#_Q31168-mappedCitation-2249881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2249881 |
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| http://purl.uniprot.org/uniprot/#_Q31210-mappedCitation-2249881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2249881 |