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http://purl.uniprot.org/citations/22503410http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22503410http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Our aim was to investigate the correlation between onset age, clinical features and HLA-DQA1/DQB1 genetic variability in myasthenia gravis (MG) patients in Southern Han Chinese.

Methods

205 MG patients and 100 controls were genotyped for HLA-DQA1 and -DQB1 using sequence-based typing (SBT) and analyzed for haplotype frequencies. Anti-acetylcholine receptor (AChR) autoantibodies were measured in all, and muscle-specific tyrosine kinase (MuSK) antibodies were tested in AChR antibody negative patients.

Results

HLA-DQA1/DQB1 haplotypes showed association only with childhood-onset MG. Haplotype DQA1*03:02/DQB1*03:03:02 (DQ9) was positively associated with the childhood-onset MG, while haplotype DQA1*02:01/DQB1*02:02 and DQA1*05:01:01/DQB1*02:01:01 (DQ2) were negatively associated with this group. Childhood-onset ocular MG patients had an extremely high phenotype frequency of DQ9 haplotype (90.1% of patients, 34.0% of controls, p≤0.0001, OR=17.8).

Conclusions

The childhood-onset ocular MG in Southern Han Chinese may present a particular subgroup of distinct genetic background. Its correlation to the HLA haplotype DQA1*03:02/DQB1*03:03:02 might explain the phenotypic difference of MG between Han Chinese and Caucasians."xsd:string
http://purl.uniprot.org/citations/22503410http://purl.org/dc/terms/identifier"doi:10.1016/j.jneuroim.2012.03.018"xsd:string
http://purl.uniprot.org/citations/22503410http://purl.uniprot.org/core/author"Lin J."xsd:string
http://purl.uniprot.org/citations/22503410http://purl.uniprot.org/core/author"Lu J."xsd:string
http://purl.uniprot.org/citations/22503410http://purl.uniprot.org/core/author"Qiao K."xsd:string
http://purl.uniprot.org/citations/22503410http://purl.uniprot.org/core/author"Lu C.Z."xsd:string
http://purl.uniprot.org/citations/22503410http://purl.uniprot.org/core/author"Lu J.H."xsd:string
http://purl.uniprot.org/citations/22503410http://purl.uniprot.org/core/author"Zhu W.H."xsd:string
http://purl.uniprot.org/citations/22503410http://purl.uniprot.org/core/author"Luo S.S."xsd:string
http://purl.uniprot.org/citations/22503410http://purl.uniprot.org/core/author"Zhao C.B."xsd:string
http://purl.uniprot.org/citations/22503410http://purl.uniprot.org/core/author"Xiao B.G."xsd:string
http://purl.uniprot.org/citations/22503410http://purl.uniprot.org/core/author"Xi J.Y."xsd:string
http://purl.uniprot.org/citations/22503410http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22503410http://purl.uniprot.org/core/name"J Neuroimmunol"xsd:string
http://purl.uniprot.org/citations/22503410http://purl.uniprot.org/core/pages"81-85"xsd:string
http://purl.uniprot.org/citations/22503410http://purl.uniprot.org/core/title"HLA-DQA1*03:02/DQB1*03:03:02 is strongly associated with susceptibility to childhood-onset ocular myasthenia gravis in Southern Han Chinese."xsd:string
http://purl.uniprot.org/citations/22503410http://purl.uniprot.org/core/volume"247"xsd:string
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