| http://purl.uniprot.org/citations/22504299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22504299 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon-γ (IFN-γ) engenders strong antiproliferative responses, in part through activation of p53. However, the long-known IFN-γ-dependent upregulation of human Trp-tRNA synthetase (TrpRS), a cytoplasmic enzyme that activates tryptophan to form Trp-AMP in the first step of protein synthesis, is unexplained. Here we report a nuclear complex of TrpRS with the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and with poly(ADP-ribose) polymerase 1 (PARP-1), the major PARP in human cells. The IFN-γ-dependent poly(ADP-ribosyl)ation of DNA-PKcs (which activates its kinase function) and concomitant activation of the tumor suppressor p53 were specifically prevented by Trp-SA, an analog of Trp-AMP that disrupted the TrpRS-DNA-PKcs-PARP-1 complex. The connection of TrpRS to p53 signaling in vivo was confirmed in a vertebrate system. These and further results suggest an unexpected evolutionary expansion of the protein synthesis apparatus to a nuclear role that links major signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/22504299 | http://purl.org/dc/terms/identifier | "doi:10.1038/nchembio.937"xsd:string |
| http://purl.uniprot.org/citations/22504299 | http://purl.uniprot.org/core/author | "Guo M."xsd:string |
| http://purl.uniprot.org/citations/22504299 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/22504299 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/22504299 | http://purl.uniprot.org/core/author | "Zhou Q."xsd:string |
| http://purl.uniprot.org/citations/22504299 | http://purl.uniprot.org/core/author | "Schimmel P."xsd:string |
| http://purl.uniprot.org/citations/22504299 | http://purl.uniprot.org/core/author | "Yang X.L."xsd:string |
| http://purl.uniprot.org/citations/22504299 | http://purl.uniprot.org/core/author | "Kapoor M."xsd:string |
| http://purl.uniprot.org/citations/22504299 | http://purl.uniprot.org/core/author | "Valdez D.M. Jr."xsd:string |
| http://purl.uniprot.org/citations/22504299 | http://purl.uniprot.org/core/author | "Kishi S."xsd:string |
| http://purl.uniprot.org/citations/22504299 | http://purl.uniprot.org/core/author | "Sajish M."xsd:string |
| http://purl.uniprot.org/citations/22504299 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22504299 | http://purl.uniprot.org/core/name | "Nat Chem Biol"xsd:string |
| http://purl.uniprot.org/citations/22504299 | http://purl.uniprot.org/core/pages | "547-554"xsd:string |
| http://purl.uniprot.org/citations/22504299 | http://purl.uniprot.org/core/title | "Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-gamma and p53 signaling."xsd:string |
| http://purl.uniprot.org/citations/22504299 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/22504299 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22504299 |
| http://purl.uniprot.org/citations/22504299 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22504299 |
| http://purl.uniprot.org/uniprot/P01579#attribution-CD4D19EDA9DEB13B3A4919B3D8B4D590 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22504299 |
| http://purl.uniprot.org/uniprot/P09874#attribution-CD4D19EDA9DEB13B3A4919B3D8B4D590 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22504299 |
| http://purl.uniprot.org/uniprot/P78527#attribution-6994883250DCF459BD14BD502B729FEC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22504299 |
| http://purl.uniprot.org/uniprot/P78527#attribution-9F5CD1CE6423FFD9D43DA5376FE1B6D0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22504299 |
| http://purl.uniprot.org/uniprot/P78527#attribution-CD4D19EDA9DEB13B3A4919B3D8B4D590 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22504299 |