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| http://purl.uniprot.org/citations/22505523 | http://www.w3.org/2000/01/rdf-schema#comment | "We hypothesized that kallikrein-related peptidase 14 (KLK14) is produced by colonic tumors and can promote tumorigenesis by activating proteinase-activated receptors (PARs). We found that KLK14 is expressed in human colon adenocarcinoma cells but not in adjacent cancer-free tissue; KLK14 mRNA, present in colon cancer, leads to KLK14 protein expression and secretion; and KLK14 signals viaPAR-2 in HT-29 cells to cause (1) receptor activation/internalization, (2) increases in intracellular calcium, (3) stimulation of ERK1/2/MAP kinase phosphorylation, and (4) cell proliferation. We suggest that KLK14, acting via PAR-2, represents an autocrine/paracrine regulator of colon tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/22505523 | http://purl.org/dc/terms/identifier | "doi:10.1515/bc-2011-231"xsd:string |
| http://purl.uniprot.org/citations/22505523 | http://purl.uniprot.org/core/author | "Virca G.D."xsd:string |
| http://purl.uniprot.org/citations/22505523 | http://purl.uniprot.org/core/author | "Chung H."xsd:string |
| http://purl.uniprot.org/citations/22505523 | http://purl.uniprot.org/core/author | "Diamandis E.P."xsd:string |
| http://purl.uniprot.org/citations/22505523 | http://purl.uniprot.org/core/author | "Hamza M."xsd:string |
| http://purl.uniprot.org/citations/22505523 | http://purl.uniprot.org/core/author | "Darmoul D."xsd:string |
| http://purl.uniprot.org/citations/22505523 | http://purl.uniprot.org/core/author | "Hollenberg M.D."xsd:string |
| http://purl.uniprot.org/citations/22505523 | http://purl.uniprot.org/core/author | "Oikonomopoulou K."xsd:string |
| http://purl.uniprot.org/citations/22505523 | http://purl.uniprot.org/core/author | "Saifeddine M."xsd:string |
| http://purl.uniprot.org/citations/22505523 | http://purl.uniprot.org/core/author | "Gratio V."xsd:string |
| http://purl.uniprot.org/citations/22505523 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22505523 | http://purl.uniprot.org/core/name | "Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22505523 | http://purl.uniprot.org/core/pages | "413-420"xsd:string |
| http://purl.uniprot.org/citations/22505523 | http://purl.uniprot.org/core/title | "Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors."xsd:string |
| http://purl.uniprot.org/citations/22505523 | http://purl.uniprot.org/core/volume | "393"xsd:string |
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