| http://purl.uniprot.org/citations/22508986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22508986 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 5 (MK5) deficiency is associated with reduced extracellular signal-regulated kinase 3 (ERK3) (mitogen-activated protein kinase 6) levels, hence we utilized the MK5 knockout mouse model to analyze the physiological functions of the ERK3/MK5 signaling module. MK5-deficient mice displayed impaired dendritic spine formation in mouse hippocampal neurons in vivo. We performed large-scale interaction screens to understand the neuronal functions of the ERK3/MK5 pathway and identified septin7 (Sept7) as a novel interacting partner of ERK3. ERK3/MK5/Sept7 form a ternary complex, which can phosphorylate the Sept7 regulators Binders of Rho GTPases (Borgs). In addition, the brain-specific nucleotide exchange factor kalirin-7 (Kal7) was identified as an MK5 interaction partner and substrate protein. In transfected primary neurons, Sept7-dependent dendrite development and spine formation are stimulated by the ERK3/MK5 module. Thus, the regulation of neuronal morphogenesis is proposed as the first physiological function of the ERK3/MK5 signaling module."xsd:string |
| http://purl.uniprot.org/citations/22508986 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.06633-11"xsd:string |
| http://purl.uniprot.org/citations/22508986 | http://purl.uniprot.org/core/author | "Simon R."xsd:string |
| http://purl.uniprot.org/citations/22508986 | http://purl.uniprot.org/core/author | "Schumacher S."xsd:string |
| http://purl.uniprot.org/citations/22508986 | http://purl.uniprot.org/core/author | "Meloche S."xsd:string |
| http://purl.uniprot.org/citations/22508986 | http://purl.uniprot.org/core/author | "Kant S."xsd:string |
| http://purl.uniprot.org/citations/22508986 | http://purl.uniprot.org/core/author | "Gaestel M."xsd:string |
| http://purl.uniprot.org/citations/22508986 | http://purl.uniprot.org/core/author | "Britsch S."xsd:string |
| http://purl.uniprot.org/citations/22508986 | http://purl.uniprot.org/core/author | "Menon M.B."xsd:string |
| http://purl.uniprot.org/citations/22508986 | http://purl.uniprot.org/core/author | "Kotlyarov A."xsd:string |
| http://purl.uniprot.org/citations/22508986 | http://purl.uniprot.org/core/author | "Turgeon B."xsd:string |
| http://purl.uniprot.org/citations/22508986 | http://purl.uniprot.org/core/author | "Brand F."xsd:string |
| http://purl.uniprot.org/citations/22508986 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22508986 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22508986 | http://purl.uniprot.org/core/pages | "2467-2478"xsd:string |
| http://purl.uniprot.org/citations/22508986 | http://purl.uniprot.org/core/title | "The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology."xsd:string |
| http://purl.uniprot.org/citations/22508986 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/22508986 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22508986 |
| http://purl.uniprot.org/citations/22508986 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22508986 |
| http://purl.uniprot.org/uniprot/O54992#attribution-4DCA061CA066CD12B7F252C8D9BC907B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22508986 |
| http://purl.uniprot.org/uniprot/O54992#attribution-EDA0140220F9BD73D89943BA27C3AFAE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22508986 |
| http://purl.uniprot.org/uniprot/Q61532#attribution-17AA6526AAE1F18473CC71ABAD6B753B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22508986 |
| http://purl.uniprot.org/uniprot/Q61532#attribution-4DCA061CA066CD12B7F252C8D9BC907B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22508986 |
| http://purl.uniprot.org/uniprot/O55131#attribution-4DCA061CA066CD12B7F252C8D9BC907B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22508986 |