| http://purl.uniprot.org/citations/22510281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22510281 | http://www.w3.org/2000/01/rdf-schema#comment | "Increased expression of the amyloid precursor protein (APP) is a crucial risk factor of Alzheimer's disease (AD). Amyloid precursor-like protein 2 (APLP2), a homologue of APP, is also suggested to participate in AD pathogenesis. Accumulating evidence suggest the regulatory role of microRNA on AD-related genes. Here we showed that the levels of miR-153 were significantly decreased at early- and late-stage of AD in APPswe/PSΔE9 murine model. Moreover, a binding site of miR-153 on APP and APLP2-3'UTR was identified, respectively, by luciferase assay. Gain and loss of function experiments demonstrated that miR-153 suppressed the expression of APP and APLP2. Using miR-153 transgenic mouse model, we testified that miR-153 downregulated the expression of APP and APLP2 protein in vivo. Furthermore, closely related expression patterns of miR-153 and APP/APLP2 during brain development indicated a physiological regulation role of miR-153 on the two genes. In a neuronal cell line treated with Aβ(42) peptides and H(2)O(2,) the levels of miR-153 varied during time-course leading to corresponding changes of APLP2 protein, indicating Aβ peptides and oxidative stress influence the expression of miR-153. Thus, miR-153 contributes to post-transcriptional regulation of APP/APLP2, suggesting a possible role for miR-153 in neuro-pathological conditions."xsd:string |
| http://purl.uniprot.org/citations/22510281 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainres.2011.10.051"xsd:string |
| http://purl.uniprot.org/citations/22510281 | http://purl.uniprot.org/core/author | "Deng W."xsd:string |
| http://purl.uniprot.org/citations/22510281 | http://purl.uniprot.org/core/author | "Huang L."xsd:string |
| http://purl.uniprot.org/citations/22510281 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/22510281 | http://purl.uniprot.org/core/author | "Liang C."xsd:string |
| http://purl.uniprot.org/citations/22510281 | http://purl.uniprot.org/core/author | "Ma C."xsd:string |
| http://purl.uniprot.org/citations/22510281 | http://purl.uniprot.org/core/author | "Qin C."xsd:string |
| http://purl.uniprot.org/citations/22510281 | http://purl.uniprot.org/core/author | "Zhu H."xsd:string |
| http://purl.uniprot.org/citations/22510281 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/22510281 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22510281 | http://purl.uniprot.org/core/name | "Brain Res"xsd:string |
| http://purl.uniprot.org/citations/22510281 | http://purl.uniprot.org/core/pages | "103-113"xsd:string |
| http://purl.uniprot.org/citations/22510281 | http://purl.uniprot.org/core/title | "MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2."xsd:string |
| http://purl.uniprot.org/citations/22510281 | http://purl.uniprot.org/core/volume | "1455"xsd:string |
| http://purl.uniprot.org/citations/22510281 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22510281 |
| http://purl.uniprot.org/citations/22510281 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22510281 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SS44-mappedCitation-22510281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22510281 |
| http://purl.uniprot.org/uniprot/#_Q06335-mappedCitation-22510281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22510281 |
| http://purl.uniprot.org/uniprot/#_Q60709-mappedCitation-22510281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22510281 |
| http://purl.uniprot.org/uniprot/#_Q61482-mappedCitation-22510281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22510281 |
| http://purl.uniprot.org/uniprot/#_Q64348-mappedCitation-22510281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22510281 |
| http://purl.uniprot.org/uniprot/#_Q3UDL6-mappedCitation-22510281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22510281 |
| http://purl.uniprot.org/uniprot/#_Q3U775-mappedCitation-22510281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22510281 |