| http://purl.uniprot.org/citations/22513370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22513370 | http://www.w3.org/2000/01/rdf-schema#comment | "Homologous chromosome segregation errors during meiosis I are common and generate aneuploid embryos. Here, we provide a reason for this susceptibility to mis-segregation by live cell imaging of mouse oocytes. Our results show that stable kinetochore-microtubule attachments form in mid-prometaphase, 3-4 hours before anaphase. This coincided with the loss of Mad2 from kinetochores and with the start of anaphase-promoting complex/cyclosome (APC/C)-mediated cyclin B1 destruction. Therefore, the spindle assembly checkpoint (SAC) ceased to inhibit the APC/C from mid-prometaphase. This timing did not coincide with bivalent congression in one-third of all oocytes examined. Non-aligned bivalents were weakly positive for Mad2, under less tension than congressed bivalents and, by live-cell imaging, appeared to be in the process of establishing correct bi-orientation. The time from when the APC/C became active until anaphase onset was affected by the rate of loss of CDK1 activity, rather than by these non-aligned bivalents, which occasionally persisted until anaphase, resulting in homolog non-disjunction. We conclude that, in oocytes, a few erroneous attachments of bivalent kinetochores to microtubules do not generate a sufficient SAC 'wait anaphase' signal to inhibit the APC/C."xsd:string |
| http://purl.uniprot.org/citations/22513370 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.077040"xsd:string |
| http://purl.uniprot.org/citations/22513370 | http://purl.uniprot.org/core/author | "Jones K.T."xsd:string |
| http://purl.uniprot.org/citations/22513370 | http://purl.uniprot.org/core/author | "Yun Y."xsd:string |
| http://purl.uniprot.org/citations/22513370 | http://purl.uniprot.org/core/author | "Lane S.I."xsd:string |
| http://purl.uniprot.org/citations/22513370 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22513370 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/22513370 | http://purl.uniprot.org/core/pages | "1947-1955"xsd:string |
| http://purl.uniprot.org/citations/22513370 | http://purl.uniprot.org/core/title | "Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tension."xsd:string |
| http://purl.uniprot.org/citations/22513370 | http://purl.uniprot.org/core/volume | "139"xsd:string |
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| http://purl.uniprot.org/uniprot/#_G3UZV6-mappedCitation-22513370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22513370 |