| http://purl.uniprot.org/citations/22513464 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22513464 | http://www.w3.org/2000/01/rdf-schema#comment | "Endoplasmic reticulum (ER) stress occurs in macrophage-rich areas of advanced atherosclerotic lesions and contributes to macrophage apoptosis and subsequent plaque necrosis. The purpose of the present study was to investigate the effects of caveolin-1 (Cav-1) on ER stress-induced apoptosis in cultured macrophages and the underlying mechanisms. RAW264.7 cells were incubated with thapsigargin (TG) to establish ER stress model. And Cav-1 expression was detected by Western blot. After being pretreated with filipin(III), a caveolae inhibitor, RAW264.7 cells were assayed with flow cytometry and confocal laser scanning microscopy to detect cell apoptosis. Moreover, p38 mitogen-activated protein kinase (MAPK) phosphorylation and C/EBP homologous protein (CHOP) expression were detected with Western blot. The results showed that Cav-1 expression was markedly increased at early stage of TG treatment (P < 0.05) and then decreased with prolonged or high dose TG treatments. The increasing of Cav-1 expression induced by TG in RAW264.7 cells was abolished under inhibition of caveolae by filipin(III) (P < 0.05). The effect of TG on apoptosis of RAW264.7 cells was further augmented after pretreatment with filipin(III) (P < 0.05). Western blotting showed that MAPK phosphorylation induced by TG was inhibited by filipin(III) in RAW264.7 cells (P < 0.05), whereas CHOP remained unchanged (P > 0.05). These results suggest that Cav-1 may play a critical role in suppressing ER stress-induced macrophages apoptosis in vitro, and one of the mechanisms may be correlated with the activation of p38 MAPK prosurvival pathway."xsd:string |
| http://purl.uniprot.org/citations/22513464 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
| http://purl.uniprot.org/citations/22513464 | http://purl.uniprot.org/core/author | "Yue W."xsd:string |
| http://purl.uniprot.org/citations/22513464 | http://purl.uniprot.org/core/author | "Sang H."xsd:string |
| http://purl.uniprot.org/citations/22513464 | http://purl.uniprot.org/core/author | "Wang J.F."xsd:string |
| http://purl.uniprot.org/citations/22513464 | http://purl.uniprot.org/core/author | "Yao S.T."xsd:string |
| http://purl.uniprot.org/citations/22513464 | http://purl.uniprot.org/core/author | "Shang Z.P."xsd:string |
| http://purl.uniprot.org/citations/22513464 | http://purl.uniprot.org/core/author | "Si Y.H."xsd:string |
| http://purl.uniprot.org/citations/22513464 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22513464 | http://purl.uniprot.org/core/name | "Sheng Li Xue Bao"xsd:string |
| http://purl.uniprot.org/citations/22513464 | http://purl.uniprot.org/core/pages | "149-154"xsd:string |
| http://purl.uniprot.org/citations/22513464 | http://purl.uniprot.org/core/title | "[Inhibitory effect of caveolin-1 on endoplasmic reticulum stress-induced apoptosis in macrophages via p38 MAPK pathway]."xsd:string |
| http://purl.uniprot.org/citations/22513464 | http://purl.uniprot.org/core/volume | "64"xsd:string |
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