| http://purl.uniprot.org/citations/22516263 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22516263 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute lymphoblastic leukemias (ALLs) are characterized by multistep oncogenic processes leading to cell-differentiation arrest and proliferation. Specific abrogation of maturation blockage constitutes a promising therapeutic option in cancer, which requires precise understanding of the underlying molecular mechanisms. We show that the cortical thymic maturation arrest in T-lineage ALLs that overexpress TLX1 or TLX3 is due to binding of TLX1/TLX3 to ETS1, leading to repression of T cell receptor (TCR) α enhanceosome activity and blocked TCR-Jα rearrangement. TLX1/TLX3 abrogation or enforced TCRαβ expression leads to TCRα rearrangement and apoptosis. Importantly, the autoextinction of clones carrying TCRα-driven TLX1 expression supports TLX "addiction" in TLX-positive leukemias and provides further rationale for targeted therapy based on disruption of TLX1/TLX3."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2012.02.013"xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Bergeron J."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Hermine O."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Cosset F.L."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Ferrier P."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Petit A."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Verhoeyen E."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Spicuglia S."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Lhermitte L."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Asnafi V."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Nadel B."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Langerak A.W."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Macintyre E.A."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Dombret H."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Radford I."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Dik W.A."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Ifrah N."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Millien C."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Le Noir S."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Payet-Bornet D."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Zacarias-Cabeza J."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Dadi S."xsd:string |
| http://purl.uniprot.org/citations/22516263 | http://purl.uniprot.org/core/author | "Vachez E."xsd:string |