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http://purl.uniprot.org/citations/22516360http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objective

To investigate the expression of Jade-1 and β-catenin and their effect in the development of renal cell carcinoma (RCC).

Methods

The expression of Jade-1 and β-catenin in 11 normal kidney tissue specimens (normal group) and 60 RCC specimens (RCC group) was determined using real-time polymerase chain reaction and immunohistochemistry. Also, their effect on early relapses of RCC was analyzed after 5 years of follow-up.

Results

The expression of Jade-1 protein in the RCC group was significantly lower than that in the normal group (0.1655 vs 0.7438, P < .05), and the expression of β-catenin protein was significantly greater than that in the normal group (0.2756 vs 0.0855, P < .05). The expression of Jade-1 mRNA in the RCC group was 0.202 times that in the normal group, which were lower (P < .05). The expression of β-catenin mRNA was 1.014 times that in the normal group (P > .05). The expression of Jade-1 protein and β-catenin protein in poorly differentiated RCC specimens was significantly lower and higher than the expression in the well-differentiated RCC specimen (P < .05), respectively. Patients with negative Jade-1 expression and positive β-catenin expression were found to have shorter survival on univariate analysis (P < .05).

Conclusion

RCC with a low expression of Jade-1 and high expression of β-catenin is associated with a poor outcome and decreased survival."xsd:string
http://purl.uniprot.org/citations/22516360http://purl.org/dc/terms/identifier"doi:10.1016/j.urology.2012.02.024"xsd:string
http://purl.uniprot.org/citations/22516360http://purl.uniprot.org/core/author"Chen S."xsd:string
http://purl.uniprot.org/citations/22516360http://purl.uniprot.org/core/author"Li C."xsd:string
http://purl.uniprot.org/citations/22516360http://purl.uniprot.org/core/author"Cai Y."xsd:string
http://purl.uniprot.org/citations/22516360http://purl.uniprot.org/core/author"Wang S."xsd:string
http://purl.uniprot.org/citations/22516360http://purl.uniprot.org/core/author"Wu X."xsd:string
http://purl.uniprot.org/citations/22516360http://purl.uniprot.org/core/author"Lian X."xsd:string
http://purl.uniprot.org/citations/22516360http://purl.uniprot.org/core/author"Duan X."xsd:string
http://purl.uniprot.org/citations/22516360http://purl.uniprot.org/core/author"Weng Z."xsd:string
http://purl.uniprot.org/citations/22516360http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22516360http://purl.uniprot.org/core/name"Urology"xsd:string
http://purl.uniprot.org/citations/22516360http://purl.uniprot.org/core/pages"485.e7-13"xsd:string
http://purl.uniprot.org/citations/22516360http://purl.uniprot.org/core/title"Expression and clinical significance of von Hippel-Lindau downstream genes: Jade-1 and beta-catenin related to renal cell carcinoma."xsd:string
http://purl.uniprot.org/citations/22516360http://purl.uniprot.org/core/volume"80"xsd:string
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