| http://purl.uniprot.org/citations/22518138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22518138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22518138 | http://www.w3.org/2000/01/rdf-schema#comment | "Nesprin-1 is a giant tail-anchored nuclear envelope protein composed of an N-terminal F-actin binding domain, a long linker region formed by multiple spectrin repeats and a C-terminal transmembrane domain. Based on this structure, it connects the nucleus to the actin cytoskeleton. Earlier reports had shown that Nesprin-1 binds to nuclear envelope proteins emerin and lamin through C-terminal spectrin repeats. These repeats can also self-associate. We focus on the N-terminal Nesprin-1 sequences and show that they interact with Nesprin-3, a further member of the Nesprin family, which connects the nucleus to the intermediate filament network. We show that upon ectopic expression of Nesprin-3 in COS7 cells, which are nearly devoid of Nesprin-3 in vitro, vimentin filaments are recruited to the nucleus and provide evidence for an F-actin interaction of Nesprin-3 in vitro. We propose that Nesprins through interactions amongst themselves and amongst the various Nesprins form a network around the nucleus and connect the nucleus to several cytoskeletal networks of the cell."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.org/dc/terms/identifier | "doi:10.1155/2012/736524"xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.org/dc/terms/identifier | "doi:10.1155/2012/736524"xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Lu W."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Lu W."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Neumann S."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Neumann S."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Muller R."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Muller R."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Noegel A.A."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Noegel A.A."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Karakesisoglou I."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Karakesisoglou I."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Sur I."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Sur I."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Munck M."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Munck M."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Rashmi R.N."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Rashmi R.N."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Taranum S."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/author | "Taranum S."xsd:string |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22518138 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |