| http://purl.uniprot.org/citations/22519658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22519658 | http://www.w3.org/2000/01/rdf-schema#comment | "AimsThis study aimed to investigate the effect of metamizole on bupropion hydroxylation related to different CYP2B6 genotype groups in healthy volunteers.MethodsSixteen healthy male volunteers (6 CYP2B6*1/*1, 6 CYP2B6*1/*6 and 4 CYP2B6*6/*6) received orally administered bupropion alone and during daily treatment with metamizole 1500 mg day(-1) (500 mg tablet taken three times daily) for 4 days. Serial blood samples were obtained up to 48 h after each bupropion dose.ResultsAfter metamizole treatment relative to bupropion alone, the geometric mean ratios (GMRs) and 90% confidence interval (CI) of the AUC(0,∞) ratio of 4-hydroxybupropion over bupropion were 1.99 (1.57, 2.55) for the CYP2B6*1/*1 group, 2.15 (1.53, 3.05) for the CYP2B6*1/*6 group and 1.86 (1.36, 2.57) for the CYP2B6*6/*6 group. The GMRs and 90% CI of bupropion were 0.695 (0.622, 0.774) for AUC(0,∞) and 0.400 (0.353, 0.449) for C(max) , respectively. The corresponding values for 4-hydroxybupropion were 1.43 (1.28, 1.53) and 2.63 (2.07, 2.92). The t(1/2) value was significantly increased for bupropion and decreased for 4-hydroxybupropion. The t(max) values of bupropion and 4-hydroxybupropion were both significantly decreased. The mean percentage changes in pharmacokinetic parameters among the CYP2B6 genotype groups were not significantly different.ConclusionsOral administration of metamizole for 4 days significantly altered the pharmacokinetics of both bupropion and its active metabolite, 4-hydroxybupropion, and significantly increased the CYP2B6-catalyzed bupropion hydroxylation in all of the subjects. Cautions should be taken when metamizole is co-administered with CYP2B6 substrate drugs."xsd:string |
| http://purl.uniprot.org/citations/22519658 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2125.2012.04304.x"xsd:string |
| http://purl.uniprot.org/citations/22519658 | http://purl.uniprot.org/core/author | "Fan L."xsd:string |
| http://purl.uniprot.org/citations/22519658 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/22519658 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/22519658 | http://purl.uniprot.org/core/author | "Chen X.P."xsd:string |
| http://purl.uniprot.org/citations/22519658 | http://purl.uniprot.org/core/author | "Liu Z.Q."xsd:string |
| http://purl.uniprot.org/citations/22519658 | http://purl.uniprot.org/core/author | "Zhou H.H."xsd:string |
| http://purl.uniprot.org/citations/22519658 | http://purl.uniprot.org/core/author | "Hu D.L."xsd:string |
| http://purl.uniprot.org/citations/22519658 | http://purl.uniprot.org/core/author | "Qin W.J."xsd:string |
| http://purl.uniprot.org/citations/22519658 | http://purl.uniprot.org/core/author | "Tan Z.R."xsd:string |
| http://purl.uniprot.org/citations/22519658 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22519658 | http://purl.uniprot.org/core/name | "Br J Clin Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/22519658 | http://purl.uniprot.org/core/pages | "999-1004"xsd:string |
| http://purl.uniprot.org/citations/22519658 | http://purl.uniprot.org/core/title | "Rapid clinical induction of bupropion hydroxylation by metamizole in healthy Chinese men."xsd:string |
| http://purl.uniprot.org/citations/22519658 | http://purl.uniprot.org/core/volume | "74"xsd:string |
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