Results

RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/22524828http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22524828http://www.w3.org/2000/01/rdf-schema#comment"

Background

The SULT1A1 Arg213His polymorphism is reported to be associated with lung cancer risk. However, this relationship remains controversial. For better understanding a meta-analysis was therefore performed.

Methods

An extensive search was performed to identify all case-control studies investigating association between SULT1A1 Arg213His polymorphism and lung cancer risk. The strength was assessed by odds ratio (OR) with the corresponding 95% confidence interval (95%CI).

Results

A total of five publications covering 1,669 cases and 1,890 controls were included in this meta-analysis. No significant association between SULT1A1 Arg213His polymorphism and lung cancer risk was observed in overall comparisons in all genetic models (dominant model: OR=1.33, 95%CI=1.00-1.76, P=0.05; additive model: OR=1.30, 95%CI=0.93-1.81, P=0.12; recessive model: OR=1.21, 95%CI=0.89-1.66, P=0.23). However, on subgroup analysis, an elevated risk in mixed populations with variant His allele was revealed in the dominant model (OR=1.66, 95% CI=1.06-2.62, P=0.03). Furthermore, the SULT1A1 Arg213His polymorphism was associated with an increased risk of lung cancer in both females and males in the dominant model (females: OR=1.72, 95%CI=1.29-2.27, P=0.00; males: OR=1.46, 95%CI=1.19-1.78, P=0.00). No significant association between this polymorphism and different smoking status (smokers and non-smokers) and the other ethnicities (Asians and Caucasians) was shown.

Conclusions

The results of this meta-analysis indicate that the SULT1A1 Arg213His polymorphism is not associated with lung cancer risk in Asians and Caucasians, but possible elevation for genotype (GA/AA) in mixed populations and males and females needs further investigation."xsd:string
http://purl.uniprot.org/citations/22524828http://purl.org/dc/terms/identifier"doi:10.7314/apjcp.2012.13.2.579"xsd:string
http://purl.uniprot.org/citations/22524828http://purl.uniprot.org/core/author"Liu L."xsd:string
http://purl.uniprot.org/citations/22524828http://purl.uniprot.org/core/author"Wang Y."xsd:string
http://purl.uniprot.org/citations/22524828http://purl.uniprot.org/core/author"Zhang Y.Y."xsd:string
http://purl.uniprot.org/citations/22524828http://purl.uniprot.org/core/author"Wang Y.J."xsd:string
http://purl.uniprot.org/citations/22524828http://purl.uniprot.org/core/author"Liao S.G."xsd:string
http://purl.uniprot.org/citations/22524828http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22524828http://purl.uniprot.org/core/name"Asian Pac J Cancer Prev"xsd:string
http://purl.uniprot.org/citations/22524828http://purl.uniprot.org/core/pages"579-583"xsd:string
http://purl.uniprot.org/citations/22524828http://purl.uniprot.org/core/title"SULT1A1 Arg213His polymorphism and lung cancer risk: a meta-analysis."xsd:string
http://purl.uniprot.org/citations/22524828http://purl.uniprot.org/core/volume"13"xsd:string
http://purl.uniprot.org/citations/22524828http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22524828
http://purl.uniprot.org/citations/22524828http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22524828
http://purl.uniprot.org/uniprot/#_P50225-mappedCitation-22524828http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22524828
http://purl.uniprot.org/uniprot/#_Q59GG0-mappedCitation-22524828http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22524828
http://purl.uniprot.org/uniprot/#_Q9UMT9-mappedCitation-22524828http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22524828
http://purl.uniprot.org/uniprot/P50225http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22524828
http://purl.uniprot.org/uniprot/Q9UMT9http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22524828
http://purl.uniprot.org/uniprot/Q59GG0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22524828