| http://purl.uniprot.org/citations/22525042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22525042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22525042 | http://www.w3.org/2000/01/rdf-schema#comment | "Allograft (H-2D(d)K(d))-induced macrophages (AIM) in C57BL/6 (H-2D(b)K(b)) mice exhibit major histocompatibility complex (MHC) haplotype-specific killing of allografts in a macrophage MHC receptor 1 (MMR1; for H-2D(d))- and MMR2 (for H-2K(d))-dependent manner. Recently, we showed HLA-B62 to be a ligand for the human homologue of mouse MMR2. In the present study, we isolated a cDNA encoding the human homologue of mouse MMR1 and found HLA-B44 to be the sole ligand specific for the human MMR1 by using beads that had been conjugated with 80 kinds of HLA proteins. Flow cytometric analyses revealed that HLA-B44-conjugated beads are specifically bound to HEK293T cells expressing human MMR1, that HLA-B44 tetramers are bound to the human MMR1-transfected HEK293T cells with a dissociation constant of 3.0×10(-9) M, and that the interaction was completely inhibited by the addition of R15 monoclonal antibody specific for mouse MMR1. The MMR1 cDNA (1537-bp) encoded a 473-amino acid polypeptide and was expressed at least in part in the brain and peripheral blood mononuclear cells (PBMCs) or monocytes, but not in granulocytes or lymphocytes. PBMCs from 7 non-H-2D(d) (non-self), but none from 5 H-2D(d) (self), in-bred mice expressed mouse MMR1 specific for H-2D(d). In contrast, PBMCs from none of the 16 human volunteers expressed HLA-B44; whereas those from only 3 of these 16 volunteers expressed human MMR1. These results reveal that human MMR1 on monocytes is a novel receptor specific for HLA-B44."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2012.04.020"xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2012.04.020"xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/author | "Hayashi M."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/author | "Hayashi M."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/author | "Shimizu T."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/author | "Shimizu T."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/author | "Kubota T."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/author | "Kubota T."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/author | "Yoshida R."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/author | "Yoshida R."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/author | "Uchiyama K."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/author | "Uchiyama K."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/author | "Yamana H."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/author | "Yamana H."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/author | "Tanigawa N."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/author | "Tanigawa N."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/author | "Tashiro-Yamaji J."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/author | "Tashiro-Yamaji J."xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/22525042 | http://purl.uniprot.org/core/name | "Gene"xsd:string |