| http://purl.uniprot.org/citations/22525750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22525750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22525750 | http://www.w3.org/2000/01/rdf-schema#comment | "A subset of tumour necrosis factor receptor (TNFR) superfamily members contain death domains in their cytoplasmic tails. Death receptor 6 (DR6) is one such member and can trigger apoptosis upon the binding of a ligand by its cysteine-rich domains (CRDs). The crystal structure of the ectodomain (amino acids 1-348) of human death receptor 6 (DR6) encompassing the CRD region was phased using the anomalous signal from S atoms. In order to explore the feasibility of S-SAD phasing at longer wavelengths (beyond 2.5 Å), a comparative study was performed on data collected at wavelengths of 2.0 and 2.7 Å. In spite of sub-optimal experimental conditions, the 2.7 Å wavelength used for data collection showed potential for S-SAD phasing. The results showed that the R(ano)/R(p.i.m.) ratio is a good indicator for monitoring the anomalous data quality when the anomalous signal is relatively strong, while d''/sig(d'') calculated by SHELXC is a more sensitive and stable indicator applicable for grading a wider range of anomalous data qualities. The use of the `parameter-space screening method' for S-SAD phasing resulted in solutions for data sets that failed during manual attempts. SAXS measurements on the ectodomain suggested that a dimer defines the minimal physical unit of an unliganded DR6 molecule in solution."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.org/dc/terms/identifier | "doi:10.1107/s0907444912004490"xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.org/dc/terms/identifier | "doi:10.1107/s0907444912004490"xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Zhao L."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Zhao L."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Shaw N."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Shaw N."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Ding W."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Ding W."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Liang W."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Liang W."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Hung L.W."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Hung L.W."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Liu Z.J."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Liu Z.J."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Wakatsuki S."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Wakatsuki S."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Jiao L."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Jiao L."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Ru H."xsd:string |
| http://purl.uniprot.org/citations/22525750 | http://purl.uniprot.org/core/author | "Ru H."xsd:string |