| http://purl.uniprot.org/citations/22528944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22528944 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNA-10b (miR-10b) was recently reported to be dysregulated in some types of cancer and to play a role in invasion and metastasis. However, effects and potential mechanisms of action of miR-10b in the metastasis of hepatocellular carcinoma (HCC) have not been explored. In this study, we confirmed that miR-10b is highly expressed in metastatic HCC tissues and in metastatic HCC cell lines by qRT-PCR. Moreover, patients with higher miR-10b expression had significantly poorer overall survival, and high miR-10b expression was an independent predictor of poor prognosis. Inhibition of miR-10b reduced cell migration and invasion in MHCC97H cells, whereas over-expression of miR-10b in HepG2 cells increased cell migration and invasion. Bioinformatics and luciferase reporter assays revealed that miR-10b binds the 3'-UTR of CADM1 mRNA and represses its translation. Western blot and qRT-PCR showed that CADM1 is inhibited by miR-10b over-expression. Silencing of CADM1 resulted in substantially increased cell motility and invasion similar to that observed with over-expression of miR-10b in HepG2 cells. These results suggest that miR-10b may positively regulate the invasion and metastasis of HCC through targeting CADM1."xsd:string |
| http://purl.uniprot.org/citations/22528944 | http://purl.org/dc/terms/identifier | "doi:10.1007/s13277-012-0396-1"xsd:string |
| http://purl.uniprot.org/citations/22528944 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/22528944 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/22528944 | http://purl.uniprot.org/core/author | "Yang F."xsd:string |
| http://purl.uniprot.org/citations/22528944 | http://purl.uniprot.org/core/author | "Zheng H."xsd:string |
| http://purl.uniprot.org/citations/22528944 | http://purl.uniprot.org/core/author | "Wang G.X."xsd:string |
| http://purl.uniprot.org/citations/22528944 | http://purl.uniprot.org/core/author | "Dou K.F."xsd:string |
| http://purl.uniprot.org/citations/22528944 | http://purl.uniprot.org/core/author | "Li Q.J."xsd:string |
| http://purl.uniprot.org/citations/22528944 | http://purl.uniprot.org/core/author | "Wang D.S."xsd:string |
| http://purl.uniprot.org/citations/22528944 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22528944 | http://purl.uniprot.org/core/name | "Tumour Biol"xsd:string |
| http://purl.uniprot.org/citations/22528944 | http://purl.uniprot.org/core/pages | "1455-1465"xsd:string |
| http://purl.uniprot.org/citations/22528944 | http://purl.uniprot.org/core/title | "MicroRNA-10b promotes migration and invasion through CADM1 in human hepatocellular carcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/22528944 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/22528944 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22528944 |
| http://purl.uniprot.org/citations/22528944 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22528944 |
| http://purl.uniprot.org/uniprot/#_A0A4Z1-mappedCitation-22528944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22528944 |
| http://purl.uniprot.org/uniprot/#_H1ZZW3-mappedCitation-22528944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22528944 |
| http://purl.uniprot.org/uniprot/#_H1ZZW4-mappedCitation-22528944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22528944 |
| http://purl.uniprot.org/uniprot/#_H1ZZW5-mappedCitation-22528944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22528944 |
| http://purl.uniprot.org/uniprot/#_H1ZZW6-mappedCitation-22528944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22528944 |
| http://purl.uniprot.org/uniprot/#_Q6MZK6-mappedCitation-22528944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22528944 |
| http://purl.uniprot.org/uniprot/#_Q9BY67-mappedCitation-22528944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22528944 |