| http://purl.uniprot.org/citations/22531175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22531175 | http://www.w3.org/2000/01/rdf-schema#comment | "Auto-regulatory feedback loops are a common molecular strategy used to optimize protein function. In Drosophila, many messenger RNAs involved in neuro-transmission are re-coded at the RNA level by the RNA-editing enzyme, dADAR, leading to the incorporation of amino acids that are not directly encoded by the genome. dADAR also re-codes its own transcript, but the consequences of this auto-regulation in vivo are unclear. Here we show that hard-wiring or abolishing endogenous dADAR auto-regulation dramatically remodels the landscape of re-coding events in a site-specific manner. These molecular phenotypes correlate with altered localization of dADAR within the nuclear compartment. Furthermore, auto-editing exhibits sexually dimorphic patterns of spatial regulation and can be modified by abiotic environmental factors. Finally, we demonstrate that modifying dAdar auto-editing affects adaptive complex behaviours. Our results reveal the in vivo relevance of auto-regulatory control over post-transcriptional mRNA re-coding events in fine-tuning brain function and organismal behaviour."xsd:string |
| http://purl.uniprot.org/citations/22531175 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms1789"xsd:string |
| http://purl.uniprot.org/citations/22531175 | http://purl.uniprot.org/core/author | "Lawrence C."xsd:string |
| http://purl.uniprot.org/citations/22531175 | http://purl.uniprot.org/core/author | "Reenan R.A."xsd:string |
| http://purl.uniprot.org/citations/22531175 | http://purl.uniprot.org/core/author | "Sugden A.U."xsd:string |
| http://purl.uniprot.org/citations/22531175 | http://purl.uniprot.org/core/author | "Sahin A."xsd:string |
| http://purl.uniprot.org/citations/22531175 | http://purl.uniprot.org/core/author | "Alpert L."xsd:string |
| http://purl.uniprot.org/citations/22531175 | http://purl.uniprot.org/core/author | "Jepson J.E."xsd:string |
| http://purl.uniprot.org/citations/22531175 | http://purl.uniprot.org/core/author | "Savva Y.A."xsd:string |
| http://purl.uniprot.org/citations/22531175 | http://purl.uniprot.org/core/author | "Dorsky J.S."xsd:string |
| http://purl.uniprot.org/citations/22531175 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22531175 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/22531175 | http://purl.uniprot.org/core/pages | "790"xsd:string |
| http://purl.uniprot.org/citations/22531175 | http://purl.uniprot.org/core/title | "Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/22531175 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/22531175 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22531175 |
| http://purl.uniprot.org/citations/22531175 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22531175 |
| http://purl.uniprot.org/uniprot/Q9NII1#attribution-520AB29A6229D3BCD10A101BD51E0290 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22531175 |
| http://purl.uniprot.org/uniprot/Q9NII1#attribution-7019A7BF9E4887E2B8B9E87269979ED3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22531175 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KG05-mappedCitation-22531175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22531175 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KHS0-mappedCitation-22531175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22531175 |