| http://purl.uniprot.org/citations/22531681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22531681 | http://www.w3.org/2000/01/rdf-schema#comment | "There is still a lack of complete consensus on immunohistochemical surrogate markers for luminal A (LA) and luminal B (LB), HER2, and basal-like subtypes of breast carcinomas and their correlation with cancer cell adhesion and invasion-promoting factors. Therefore, early-stage invasive ductal breast cancer patients (N=209) were recruited to the study and divided into 4 subtypes, on the basis of the expression of the estrogen/progesterone receptor and HER2 (LA: 74.4% of cases; LB: 7.8%; HER2: 5.6%; and triple-negative phenotype: 12.2%). Regardless of the above-mentioned classification, we divided all carcinomas into 2 groups: carcinomas expressing at least 1 basal marker [cytokeratine (CK)5/6, CK5, vimentin, epidermal growth factor receptor, or aberrant CK8/18 expression-membranous or in <10% of cells] versus carcinomas negative for basal markers. Then we studied the relationships between the above subtypes (2 classifications) and (i) the expression of adhesion molecules (Ep-CAM, P-cadherin), (ii) matrix metalloproteinases (MMP)-2, (iii) the proliferation index (MIB-1 LI), and (iv) the microvascular density. We confirmed that triple-negative phenotypes are characterized by basal marker expression, a high tumor grade, and high MIB-1 LI. In this subtype, we found MMP-2 expression in stromal leukocytes less frequently. Both LA carcinomas and carcinomas negative for basal markers were more often negative for epithelial cell adhesion molecule (Ep-CAM) and P-cadherin. Moreover, we noted a higher mean value of microvascular density in CK5/6 and Ep-CAM-immunopositive tumors, carcinomas with aberrant CK8/18 expression, and carcinomas with no or strong expression of MMP-2 in stromal fibroblast-like cells. These results might suggest that mechanisms of stroma remodeling and carcinogenesis (Ep-CAM is the suggested marker of breast progenitors) may differ between breast cancer subtypes."xsd:string |
| http://purl.uniprot.org/citations/22531681 | http://purl.org/dc/terms/identifier | "doi:10.1097/pai.0b013e31824f21af"xsd:string |
| http://purl.uniprot.org/citations/22531681 | http://purl.uniprot.org/core/author | "Rys J."xsd:string |
| http://purl.uniprot.org/citations/22531681 | http://purl.uniprot.org/core/author | "Adamczyk A."xsd:string |
| http://purl.uniprot.org/citations/22531681 | http://purl.uniprot.org/core/author | "Majchrzyk K."xsd:string |
| http://purl.uniprot.org/citations/22531681 | http://purl.uniprot.org/core/author | "Malecki K."xsd:string |
| http://purl.uniprot.org/citations/22531681 | http://purl.uniprot.org/core/author | "Niemiec J.A."xsd:string |
| http://purl.uniprot.org/citations/22531681 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22531681 | http://purl.uniprot.org/core/name | "Appl Immunohistochem Mol Morphol"xsd:string |
| http://purl.uniprot.org/citations/22531681 | http://purl.uniprot.org/core/pages | "550-560"xsd:string |
| http://purl.uniprot.org/citations/22531681 | http://purl.uniprot.org/core/title | "Relationships between immunophenotype, Ki-67 index, microvascular density, Ep-CAM/P-cadherin, and MMP-2 expression in early-stage invasive ductal breast cancer."xsd:string |
| http://purl.uniprot.org/citations/22531681 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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