| http://purl.uniprot.org/citations/22531926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22531926 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell survival transcription factor FOXO3 has been recently implicated in moderating pro-inflammatory cytokine production by dendritic cells (DCs), but the molecular mechanisms are unclear. It was suggested that FOXO3 could antagonize NF-κB activity, while IKK-β was demonstrated to inactivate FOXO3, suggesting a cross-talk between the two pathways. Therefore, FOXO3 activity must be tightly regulated to allow for an appropriate inflammatory response. Here, we show that in human monocyte-derived DCs (MDDCs), FOXO3 is able to antagonize signaling intermediates downstream of the Toll-like receptor (TLR) 4, such as NF-κB and interferon regulatory factors (IRFs), resulting in inhibition of interferon (IFN)-β expression. We also demonstrate that the activity of FOXO3 itself is regulated by IKK-ε, a kinase involved in IFN-β production, which phosphorylates and inactivates FOXO3 in response to TLR4 agonists. Thus, we identify FOXO3 as a new IKK-ε-controlled check-point of IRF activation and regulation of IFN-β expression, providing new insight into the role of FOXO3 in immune response control."xsd:string |
| http://purl.uniprot.org/citations/22531926 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201141969"xsd:string |
| http://purl.uniprot.org/citations/22531926 | http://purl.uniprot.org/core/author | "Lanfrancotti A."xsd:string |
| http://purl.uniprot.org/citations/22531926 | http://purl.uniprot.org/core/author | "Udalova I.A."xsd:string |
| http://purl.uniprot.org/citations/22531926 | http://purl.uniprot.org/core/author | "Saliba D."xsd:string |
| http://purl.uniprot.org/citations/22531926 | http://purl.uniprot.org/core/author | "Blazek K."xsd:string |
| http://purl.uniprot.org/citations/22531926 | http://purl.uniprot.org/core/author | "Luron L."xsd:string |
| http://purl.uniprot.org/citations/22531926 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22531926 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22531926 | http://purl.uniprot.org/core/pages | "1030-1037"xsd:string |
| http://purl.uniprot.org/citations/22531926 | http://purl.uniprot.org/core/title | "FOXO3 as a new IKK-epsilon-controlled check-point of regulation of IFN-beta expression."xsd:string |
| http://purl.uniprot.org/citations/22531926 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/22531926 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22531926 |
| http://purl.uniprot.org/citations/22531926 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22531926 |
| http://purl.uniprot.org/uniprot/#_A0A075B7B4-mappedCitation-22531926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22531926 |
| http://purl.uniprot.org/uniprot/#_Q14164-mappedCitation-22531926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22531926 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GV38-mappedCitation-22531926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22531926 |
| http://purl.uniprot.org/uniprot/#_A0A856PRE8-mappedCitation-22531926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22531926 |
| http://purl.uniprot.org/uniprot/#_B5BUQ5-mappedCitation-22531926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22531926 |
| http://purl.uniprot.org/uniprot/#_B4E1P9-mappedCitation-22531926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22531926 |
| http://purl.uniprot.org/uniprot/#_P01574-mappedCitation-22531926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22531926 |
| http://purl.uniprot.org/uniprot/#_O43524-mappedCitation-22531926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22531926 |
| http://purl.uniprot.org/uniprot/#_Q15943-mappedCitation-22531926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22531926 |
| http://purl.uniprot.org/uniprot/#_Q68DV3-mappedCitation-22531926 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22531926 |