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http://purl.uniprot.org/citations/22536166http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22536166http://www.w3.org/2000/01/rdf-schema#comment"

Background

Vitamin C is an essential nutrient for maintaining human life. Vitamin C insufficiency in the plasma is closely related with the development of scurvy. However, in vivo kinetics of vitamin C regarding its storage and consumption is still largely unknown.

Methods

We used Gulo(-/-) mice, which cannot synthesize vitamin C like human. Vitamin C level in plasma and organs from Gulo(-/-) mice was examined, and it compared with the level of wild-type mice during 5 weeks.

Results

The significant weight loss of Gulo(-/-) mice was shown at 3 weeks after vitamin C withdrawal. However, there was no differences between wild-type and vitamin C-supplemented Gulo(-/-) mice (3.3 g/L in drinking water). The concentration of vitamin C in plasma and organs was significantly decreased at 1 week after vitamin C withdrawal. Vitamin C is preferentially deposited in adrenal gland, lymph node, lung, and brain. There were no significant changes in the numbers and CD4/CD8 ratio of splenocytes in Gulo(-/-) mice with vitamin C withdrawal for 4 weeks. And the architecture of spleen in Gulo(-/-) mice was disrupted at 5 weeks after vitamin C withdrawal.

Conclusion

The vitamin C level of Gulo(-/-) mice was considerably decreased from 1 week after vitamin C withdrawal. Vitamin C is preferentially stored in some organs such as brain, adrenal gland and lung."xsd:string
http://purl.uniprot.org/citations/22536166http://purl.org/dc/terms/identifier"doi:10.4110/in.2012.12.1.18"xsd:string
http://purl.uniprot.org/citations/22536166http://purl.uniprot.org/core/author"Kim Y."xsd:string
http://purl.uniprot.org/citations/22536166http://purl.uniprot.org/core/author"Kim H."xsd:string
http://purl.uniprot.org/citations/22536166http://purl.uniprot.org/core/author"Kim H.R."xsd:string
http://purl.uniprot.org/citations/22536166http://purl.uniprot.org/core/author"Yu Y."xsd:string
http://purl.uniprot.org/citations/22536166http://purl.uniprot.org/core/author"Kang J.S."xsd:string
http://purl.uniprot.org/citations/22536166http://purl.uniprot.org/core/author"Bae S."xsd:string
http://purl.uniprot.org/citations/22536166http://purl.uniprot.org/core/author"Lee W.J."xsd:string
http://purl.uniprot.org/citations/22536166http://purl.uniprot.org/core/author"Hwang Y.I."xsd:string
http://purl.uniprot.org/citations/22536166http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22536166http://purl.uniprot.org/core/name"Immune Netw"xsd:string
http://purl.uniprot.org/citations/22536166http://purl.uniprot.org/core/pages"18-26"xsd:string
http://purl.uniprot.org/citations/22536166http://purl.uniprot.org/core/title"The analysis of vitamin C concentration in organs of gulo(-/-) mice upon vitamin C withdrawal."xsd:string
http://purl.uniprot.org/citations/22536166http://purl.uniprot.org/core/volume"12"xsd:string
http://purl.uniprot.org/citations/22536166http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22536166
http://purl.uniprot.org/citations/22536166http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22536166
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http://purl.uniprot.org/uniprot/Q8JZZ1http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22536166
http://purl.uniprot.org/uniprot/P58710http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22536166
http://purl.uniprot.org/uniprot/Q8K156http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22536166